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| Product | Description | |
|---|---|---|
| PF-04217903 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF-04217903 | PF-04136309 is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation. Synonyms: PF-04217903; PF 04217903; PF04217903; PF-4217903; PF4217903; PF 4217903. Grades: >98%. CAS No. 956905-27-4. Molecular formula: C19H16N8O. Mole weight: 372.392. |  |
| PF-04217903 | PF-04217903 is a potent ATP-competitive c-Met kinase inhibitor with K i of 4.8 nM for human c-Met. PF-04217903 shows more than 1,000-fold selectivity relative to 208 kinases. Antiangiogenic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956905-27-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12017. |  |
| PF-04217903 mesylate | PF-04217903 mesylate is a potent ATP-competitive c-Met kinase inhibitor with K i of 4.8 nM for human c-Met. PF-04217903 mesylate shows more than 1,000-fold selectivity relative to 208 kinases. Antiangiogenic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956906-93-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12017A. | |
| PF-04217903 methanesulfonate | PF-04217903 methanesulfonate is a selective ATP-competitive c-Met inhibitor and is susceptible to oncogenic mutations (no activity to Y1230C mutant). It showed more than 1000-fold greater selectivity against c-Met kinase over 150 other kinases. It displays similar potency to inhibit the activity of c-Met-H1094R, c-Met-R988C, and c-Met-T1010I, but has no inhibitory activity against c-Met-Y1230C. It showed antitumor activity in tumor models where c-Met is activated by mechanisms including c-Met gene amplification, HGF/c-Met autocrine loop formation or c-Met overexpression. It suppressed proliferation of c-Met-amplified GTL-16 and H1993cells. It induced apoptosis in GTL-16 cells. It inhibited the phosphorylation of c-Met and suppressed tumor growth. Synonyms: PF-04217903 methanesulfonate; PF 04217903 methanesulfonate; PF04217903 methanesulfonate. Grades: >98%. CAS No. 956906-93-7. Molecular formula: C20H20N8O4S. Mole weight: 468.49. | |
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