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| Product | Description | |
|---|---|---|
| PF-04929113 | PF-04929113, also known as SNX-5422, is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate; SNX5422; SNX-5422; SNX 5422; PF4929113; PF-4929113; PF 4929113; PF04929113; PF 04929113; PF-04929113. Grades: >97%. CAS No. 908115-27-5. Molecular formula: C25H30F3N5O4. Mole weight: 521.53. |  |
| PF-04929113 mesylate | The methlate salt form of PF-04929113 that has potential antineoplastic activity targeting Hsp90. It could probably result in the proteasomal degradation of oncogenic client proteins and the restrain of tumor cell proliferation. Uses: The methlate salt form of pf-04929113 that has potential antineoplastic activity targeting hsp90. Synonyms: PF-04929113 mesylate; PF 04929113 mesylate; PF04929113 mesylate; (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate mesylate; PF-04929113 mesylate; SNX5422; SNX-5422; SNX 5422; PF4929113; PF-4929113; PF 4929113; PF04929113; PF 04929113; PF-04929113. Grades: 98%. CAS No. 1173111-67-5. Molecular formula: C26H34F3N5O7S. Mole weight: 617.64. | |
| SNX-5422 | SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a K d of 41 nM, and also induces Her-2 degradation, with an IC 50 of 37?nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-04929113. CAS No. 908115-27-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10213. |  |
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