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Product | Description | |
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PF-543 Quick inquiry Where to buy Suppliers range | PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(I) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. Uses: Enzyme inhibitors. Synonyms: PF-543; PF543; PF 543. Grades: 0.98. CAS No. 1415562-82-1. Molecular formula: C27H31NO4S. Mole weight: 465.60. | |
PF-543 Citrate Quick inquiry Where to buy Suppliers range | Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Synonyms: PF543 Citrate; PF 543 Citrate. Grades: >98%. CAS No. 1415562-83-2. Molecular formula: C33H39NO11S. Mole weight: 657.73. | |
PF-543 hydrochloride Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of PF-543, a novel SphK1 inhibitor that could exhibit activity in induceing necrosis in human colorectal cancer cells in biological studies. IC50: 2 nM; Ki: 3.6 nM. Synonyms: PF-543 hydrochloride; PF 543 hydrochloride; PF543 hydrochloride; (2R) -1-[[4-[[3-Methyl-5-[ (phenylsulfonyl) methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol Hydrochloride. Grades: 98%. CAS No. 1706522-79-3. Molecular formula: C27H31NO4S.HCl. Mole weight: 502.07. | |
PF-543 hydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1415562-82-1 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 502.07. Catalog: ALP1415562821. Assay: ≥98% (HPLC). | |
(2R) -1- [ [4- [ [3-Methyl-5- [ (phenylsulfonyl) methyl] phenoxy] methyl] phenyl] methyl] -2-pyrrolidinemethanol Quick inquiry Where to buy Suppliers range | (2R) -1- [ [4- [ [3-Methyl-5- [ (phenylsulfonyl) methyl] phenoxy] methyl] phenyl] methyl] -2-pyrrolidinemethanol. Group: Biochemicals. Alternative Names: PF-543. Grades: Highly Purified. CAS No. 1415562-82-1. Pack Sizes: 5mg. Molecular Formula: C27H31NO4S, Molecular Weight: 465.6. US Biological Life Sciences. | Worldwide |