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| Product | Description | |
|---|---|---|
| PH-797804 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PH-797804 | PH-797804 is a ATP-competitive, selective p38?/p38? inhibitor (IC50=26 nM and Ki=5.8 nM for p38?; Ki=40 nM for p38?) and does not inhibit JNK2. Uses: Scientific research. Group: Signaling pathways. CAS No. 586379-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10403. |  |
| PH-797804 | PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase. PH-797804 exhibited exceptionally high specificity against MAP kinases and the related kinases. No cross-reactivity was observed in large panels of kinase screens (selectivity ratio of >500-fold). In cellular assays, PH-797804 demonstrated superior potency and selectivity consistent with the biochemical measurements. PH-797804 has met safety criteria in human phase I studies and is under clinical development for several inflammatory conditions. Understanding the rationale for selectivity at the molecular level helps elucidate the biological function and design of specific p38alpha kinase inhibitors. Synonyms: PH 797804; PH797804; 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide. CAS No. 586379-66-0. Molecular formula: C22H19BrF2N2O3. Mole weight: 477.30. |  |
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