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| Product | Description | |
|---|---|---|
| PHA 568487 | PHA 568487 is an orally active and brain penetrant agonist of the alpha 7 nicotinic acetylcholine receptor (Ki = 44 and 2800 for α7 and 5-HT3 respectively, IC50=> 100 μM for α3β4 and α1β1δγ respectively, and % inhibition is < 1 and 5% for α4β2 and hERG respectively), which was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability. Synonyms: PHA 568487; PHA568487; PHA-568487; N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate. Grades: ≥99% by HPLC. CAS No. 527680-57-5. Molecular formula: C16H20N2O3.C4H4O4. Mole weight: 404.41. |  |
| PHA 568487 | Selective α7 nAChR agonist. Agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively, IC50 values are > 100 μM for α3 β4 and α1 β1δγ respectively, and % inhibition is < 1 and 5% for α4 β2 and hERG respectively). Orally active and brain penetrant. Group: Biochemicals. Alternative Names: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide Fumarate. Grades: Highly Purified. CAS No. 527680-57-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 404.41. US Biological Life Sciences. |  Worldwide |
| PHA 568487 free base | PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor ( α-7 nAchR ) agonist. PHA 568487 free base reduces neuroinflammation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 527680-56-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129674. |  |
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