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| Product | Description | |
|---|---|---|
| PHA-665752 | PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase ( K i=4 nM; IC 50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 477575-56-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11107. |  |
| PHA-665752-d8 Hydrate | PHA-665752-d8 Hydrate. Group: Biochemicals. Alternative Names: (3Z) -5-[[ (2, 6-dichlorophenyl) methyl]sulfonyl]-3-[[3, 5-dimethyl-4-[[ (2R) -2- (1-pyrrolidinylmethyl) -1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1, 3-dihydro-2H-indol-2-one-d8 Hydrate; PHA 665752-d8 Hydrate. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C32H26D8Cl2N4O4S; xH2O, Molecular Weight: 649.66. US Biological Life Sciences. |  Worldwide |
| PHA-665752 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PHA-665752 Hydrate | PHA-665752 ia a c-Met kinase inhibitor. PHA-665752 is ATP-competitive, an active-site inhibitor with greater than 50-fold selectivity for c-Met vs a panel of tyrosine and serine-threonine kinases. Group: Biochemicals. Alternative Names: (3Z) -5-[[ (2, 6-dichlorophenyl) methyl]sulfonyl]-3-[[3, 5-dimethyl-4-[[ (2R) -2- (1-pyrrolidinylmethyl) -1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1, 3-dihydro-2H-indol-2-one Hydrate; PHA 665752 Hydrate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PHA665752 | PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling c-Met is highly expressed in most tumors from patients with advanced-stage, metastatic NBL. Furthermore, using the NBL cell line SH-EP as a model, PHA665752 was shown to inhibit cMet/HGF/SF signaling in vitro, suggesting c-Met inhibitors may have efficacy for blocking local progression and/or metastatic spread of c-Met-positive NBL in vivo. These are novel findings for this disease and suggest that further studies of agents targeting the c-Met/HGF axis in NBL are warranted. Synonyms: PHA-665752; PHA 665752. Grades: >98%. CAS No. 477575-56-7. Molecular formula: C32H34Cl2N4O4S. Mole weight: 641.608. |  |
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