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| Product | Description | |
|---|---|---|
| Phenoxodiol | Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DEHYDROEQUOL;7,4-DIHYDROXYISOFLAV-3-ENE;PHENOXODIOL;Haginin E;Idronoxil;3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol;PhenoxodiolHaginin EIdronoxil;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-. Product Category: Inhibitors. Appearance: Solid. CAS No. 81267-65-4. Molecular formula: C15H12O3. Mole weight: 240.25. Purity: 0.9976. Canonical SMILES: OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1. Product ID: ACM81267654. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Phenoxodiol | Phenoxodiol is a synthetic flavonoid derivative. Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death. Synonyms: Idronoxil; Dehydroequol; Haginin E; NV-06; NV06; NV 06; 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-; 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; 7,4'-Dihydroxyisoflav-3-ene; 7-hydroxy-3-hydroxyphenyl-1H-benzopyran. Grades: ≥98%. CAS No. 81267-65-4. Molecular formula: C15H12O3. Mole weight: 240.25. |  |
| Dehydroequol diacetate | Dehydroequol diacetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PHENOXODIOL DIACETATE;DEHYDROEQUOL DIACETATE. Product Category: Heterocyclic Organic Compound. CAS No. 81267-66-5. Molecular formula: C19H16O5. Mole weight: 198.12964. Purity: 0.96. IUPACName: [4-(7-acetyloxy-2H-chromen-3-yl)phenyl] acetate. Canonical SMILES: CC(=O)OC1=CC=C(C=C1)C2=CC3=C(C=C(C=C3)OC(=O)C)OC2. Density: 1.257g/cm³. Product ID: ACM81267665. Alfa Chemistry ISO 9001:2015 Certified. | |
| NV-128 | NV-128 is a novel isoflavone derivative, which has been shown in pre-clinical studies to promote cancer cell death in multi drug resistant cancer cells by inducing caspase-independent DNA degradation and cancer cell death via the AKT-mTOR pathway. In contrast to phenoxodiol and triphendiol, NV-128 has been shown to induce caspase-independent DNA degradation and cancer cell death. It appears that in conjunction with autophagy induction, NV-128 induces caspase independent cell death via the AKT-mTOR pathway resulting in beclin sequestration of Bcl-2, Bax up-regulation and mitochondrial depolarization. As a consequence, endonuclease G translocates to the nucleus where it initiates DNA degradation and cell death. This offers an opportunity for use as a monotherapy in chemoresistant cancers and enhanced efficacy against cancer targets less susceptible to phenoxodiol. The option for co-administration of combinations of these drugs is also under investigation to extend the potential therapeutic range of this unique class of oncology compounds. Synonyms: NV-128; NV 128; NV128. CAS No. 1210335-22-0. | |
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