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| Product | Description | |
|---|---|---|
| Phorbol 12,13-dibutyrate | ?98% (TLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate, a protein kinase C activator, stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Uses: Carcinogens. Synonyms: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester; 12,13-Dibutyrate, Phorbol; Phorbol 12,13 Dibutyrate; Phorbol 12,13-Dibutyrate; Phorbol-12,13-Dibutyrate. CAS No. 37558-16-0. Molecular formula: C28H40O8. Mole weight: 504.61. |  |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 37558-16-0. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phorbol dibutyrate; PDBu. CAS No. 37558-16-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18985. |  |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. | |
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