Phospholipase Suppliers USA
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Product | Description | |
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Phospholipase C, gamma 1, pY783, Negative Control Peptide (Non-phosphorlyated) Quick inquiry Where to buy Suppliers range | Phospholipase C, gamma 1, pY783, Negative Control Peptide (Non-phosphorlyated). Group: Molecular Biology. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Phospholipase C, gamma 1, pY783, Positive Control Peptide (Phosphorlyated) Quick inquiry Where to buy Suppliers range | Phospholipase C, gamma 1, pY783, Positive Control Peptide (Phosphorlyated). Group: Molecular Biology. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
sPLA2-IIA Inhibitor II, KH064 ( (S) -5- (4- (benzyloxy) phenyl) -4- (7-phenylheptanamido) pentanoic Acid, Phospholipase A2 Group IIA Inhibitor II, PLA2g2a Inhibitor II) Quick inquiry Where to buy Suppliers range | A reversible, potent, and selective sPLA2-IIA/PLA2g2a (phospholipase A2 group IIA) inhibitor (IC50 = 29nM) that displays much reduced potency against sPLA2-V/PLA2g5 (PLA2 group V; IC50 = 2uM) and is reported not to affect the activity of cytosolic cPLA2, Ca2+-independent iPLA2, 30 human GPCRs, and 25 other enzymes. In addition to being useful in studying PLA2g2a-mediated cellular responses in cultures in vitro (100% inhibition of LPS-induced PGE2 production in HMC-1 cells; 15 min 10uM pretreatment), KH064 is orally available in rats and efficacious in various rat disease models in vivo (5mg/kg p.o.), including adjuvant-induced arthritis, spontaneous hypertension, high fat diet-induced metabolic disorders. Comparing to the substrate-competitive inhibitor c(2NapA)LS(2NapA)R, KH064 also effectively chelates sPLA2-IIA active site Ca2+ in addition to targeting the enzyme's N-terminal lipid substrate binding site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
1, 12-Dodecanediylbis (tributylphosphonium) Dibromide Quick inquiry Where to buy Suppliers range | An antigungal agent that is a potent inhibitor of phospholipases from the fungal pathogen Cryptococcus neoformans. Group: Biochemicals. Grades: Highly Purified. CAS No. 99372-74-4. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
12:0 Diether PC:Chol (70:30) Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
13:0 Diether PC:Chol (70:30) Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
14:0 Diether PC:Chol (70:30) Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
16:0 Diether PC:Chol (70:30) Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
16:0 Diether PC Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
18:0 Diether PC:Chol (70:30) Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
18:0 Diether PC Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
18:1 Diether PC:Chol (70:30) Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
18:1 Diether PC Liposomes Quick inquiry Where to buy Suppliers range | Ether lipids are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. One hand, the ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH, one the other hand, stability properties of the liposomes is enhanced by bipolar lipids, and the saturated alkyl chains gives stability towards degradation in oxidative conditions. Besides, the unusual stereochemistry of the glycerol backbone enhance the resistance against the attacks by other organism phospholipases. Uses: Control liposomes, membrane biology. Group: Plain liposome. | |
1-Oleoyl lysophosphatidic acid Quick inquiry Where to buy Suppliers range | 1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase. Synonyms: 1-Oleoyl-sn-glycerol 3-phosphate; Oleoyl LPA; 18:1 LPA; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate; LysoPA(18:1). Grades: ≥95%. CAS No. 65528-98-5. Molecular formula: C21H41O7P. Mole weight: 436.50. | |
1-Palmitoyl-2-(L-α-phosphatidylinositol) Sodium Salt Quick inquiry Where to buy Suppliers range | 1-Palmitoyl-2-(L-α-phosphatidylinositol) Sodium Salt is a substrate for phospholipase C that contains mainly linoleic and palmitic acids. Group: Biochemicals. Grades: Highly Purified. CAS No. 383907-36-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C43H78NaO13P, Molecular Weight: 857.04. US Biological Life Sciences. | Worldwide |
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol Sodium Salt Quick inquiry Where to buy Suppliers range | Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues generated by substitution of ethanol for the lipid headgroup by the phospholipase D enzyme. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is theoretically 100%. Group: Biochemicals. Grades: Highly Purified. CAS No. 322647-55-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C39H74NaO8P, Molecular Weight: 724.96. US Biological Life Sciences. | Worldwide |
2,2,2-Trifluoroethanol-1,1-d2 Quick inquiry Where to buy Suppliers range | Isotope labelled 2,2,2-Trifluoroethanol (T790175), is used in the synthesis of competitive inhibitors for phospholipase A2. Used in the preparation of a key Efavirenz (E425000) intermediate, a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 132248-58-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C2HD2F3O, Molecular Weight: 102.05. US Biological Life Sciences. | Worldwide |
2-Chloro-1,3,2-dioxaphospholane-2-oxide Quick inquiry Where to buy Suppliers range | 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α -naphthyl phosphoryl choline as a method to detect phospholipase C activity. Group: Biochemicals. Alternative Names: Ethylene phosphorochloridate; Phosphorochloridic Acid, Cyclic Ethylene Ester; 2-Chloro-2-oxido-1,3,2-dioxaphospholane; 2-Chloro-2-oxo-1,3,2-dioxaphospholane; Cyclic ethylene phosphorochloridate; Ethylene Chlorophosphate. Grades: Highly Purified. CAS No. 6609-64-9. Pack Sizes: 5g, 25g. Molecular Formula: C?H?ClO?P, Molecular Weight: 142.48. US Biological Life Sciences. | Worldwide |
2-Nitro-4-carboxyphenyl N,N-Diphenylcarbamate Quick inquiry Where to buy Suppliers range | 2-Nitro-4-carboxyphenyl N,N-Diphenylcarbamate is an inhibitor of Phospholipase C. Also functions in the inhibition of blood coagulation factors II, VII, IX, and X, serine esterase inhibition, and plant-growth regulator. Group: Biochemicals. Grades: Highly Purified. CAS No. 10556-88-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C20H14N2O6, Molecular Weight: 378.33. US Biological Life Sciences. | Worldwide |
3-Bromo-4-phenyl-2-butanone Quick inquiry Where to buy Suppliers range | 3-Bromo-4-phenyl-2-butanone is used as a reagent in the synthesis of indolizine and indene derivatives which are potent inhibitors of secretory phospholipase A2 (sPLA2). Group: Biochemicals. Grades: Highly Purified. CAS No. 55985-68-7. Pack Sizes: 1g, 10g. Molecular Formula: C10H11BrO, Molecular Weight: 227.1. US Biological Life Sciences. | Worldwide |
4-Aminophenyl a-D-mannopyranoside 6-phosphate Quick inquiry Where to buy Suppliers range | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Synonyms: 4-Aminophenyl 6-phospho-alpha-mannopyranoside; 4-Aminophenyl 6-phospho-alpha-D-mannopyranoside. CAS No. 74160-60-4. Molecular formula: C12H18NO9P. Mole weight: 351.25. | |
4-Methylumbelliferyl phosphocholine Quick inquiry Where to buy Suppliers range | 4-Methylumbelliferyl phosphocholine, a highly sought-after fluorescent substrate within the biomedical industry, boasts immense significance in elucidating the intricacies surrounding phosphocholine-hydrolyzing enzymes. Touted for its efficacy in ascertaining the activity of microbial phospholipases, pivotal actors in the realm of bacterial and fungal pathogenesis, this substrate undeniably opens Pandora's box of insights into the multifaceted mechanics governing diverse infectious diseases. CAS No. 97055-84-0. Molecular formula: C15H20NO6P. Mole weight: 341.30. | |
5-Methoxy-2-methylindoline Quick inquiry Where to buy Suppliers range | Used in the preparation of indole-3-acetamides, inhibitors of phospholipase A2. Group: Biochemicals. Alternative Names: 2-Methyl-5-methoxyindoline; 2,3-Dihydro-5-methoxy-2-methyl-1H-indole. Grades: Highly Purified. CAS No. 41568-27-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
740 Y-P Quick inquiry Where to buy Suppliers range | 740 Y-P is a cell-permeable phosphopeptide activator of PI3K. It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. And it displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro. Synonyms: PDGFR 740Y-P; H-Arg-Gln-aIle-Lys-aIle-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-Tyr(PO3H2)-Met-Asp-Met-Ser-OH. Grades: 98.38 %. CAS No. 1236188-16-1. Molecular formula: C141H222N43O39PS3. Mole weight: 3270.70. | |
AACOCF Quick inquiry Where to buy Suppliers range | AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro. Synonyms: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one; Arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane. CAS No. 149301-79-1. Molecular formula: C21H31F3O. Mole weight: 356.47. | |
ACA - CAS 110683-10-8 Quick inquiry Where to buy Suppliers range | A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 110683-10-8. Pack Sizes: 25MG. Mole weight: 337.41. Catalog: AP110683108. Assay: ≥99% (HPLC). | |
Alexidine dihydrochloride Quick inquiry Where to buy Suppliers range | Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus. Synonyms: 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2); 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride; Biguanide, 1,1'-hexamethylenebis[5-(2-ethylhexyl)-, dihydrochloride; 1,6-Bis(2-ethylhexylbiguanido)hexane dihydrochloride; Alexidine hydrochloride; Hexamethylenebis(2-ethylhexyl)biguanide dihydrochloride. Grades: >98%. CAS No. 1715-30-6. Molecular formula: C26H58N10Cl2. Mole weight: 581.71. | |
all cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | all cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester is an omega-3 fatty acid agent. It is important polyunsaturated fatty acid of the marine food chain. It serves as a precursor of the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid by the extra double bond between the third and fourth carbons from the "methyl end" of the molecule. It reduces non-high-density lipoprotein cholesterol, lipoprotein-associated phospholipase A2, apolipoprotein B, very low-density lipoprotein cholesterol, and total cholesterol. It reduces the TG levels and improved other lipid parameters without significantly increasing the LDL cholesterol levels. It is used in combination with changes in diet to lower triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia. It has anti-inflammatory and cardiovascular benefits. It may alter the expression of genes related to fatty acid metabolism. It was the second class of fish oil-based drug to be approved for use as a drug. It was developed by Amarin Corporation. It has been listed. Uses: All cis-5,8,11,14,17-eicosapentaenoic acid ethyl ester reduces non-high-density lipoprotein cholesterol, lipoprotein-associated phospholipase a2, apolipoprotein b, very low-density lipoprotein cholesterol, and total cholesterol. it has anti-inflammatory and cardiovascular benefits. Synonyms: Eicosapentaenoic Acid Ethyl Ester;(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester;(all-Z)-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester;cis-Eicosapentaenoic Acid Ethyl Ester;Ethyl icosapentate; Epadel;Ethyl eicosapentaenoate;Vascepa;EPA ethyl ester;Ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate. Grades: >98%. CAS No. 86227-47-6. Molecular formula: C22H34O2. Mole weight: 330.50. | |
Anti-Inflammatory Peptide 1 Acetate Quick inquiry Where to buy Suppliers range | Anti-Inflammatory Peptide 1 Acetate possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2), whose increased presence and activity results in inflammation and pain at certain bodily sites. Molecular formula: C47H86N12O16S2. Mole weight: 1139.39. | |
ARN19874 Quick inquiry Where to buy Suppliers range | ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 μM. ARN19874 is the first selective, cell-active inhibitor of NAPE-PLD. It is significantly less potent on the Q320A mutant, and it can cause a substantial accumulation of non-metabolized NAPE species iuman HEK-293 cells at 50 uM. Uses: Enzyme inhibitors. Synonyms: 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide. Grades: ≥98%. CAS No. 2190502-57-7. Molecular formula: C19H14N4O4S. Mole weight: 394.41. | |
ASB14780 Quick inquiry Where to buy Suppliers range | ASB14780 is a potent and oral inhibitor of cytosolic phospholipase A2α (cPLA2α; IC50 = 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay) with anti-inflammatory property in ear edema and asthma models. ASB14780 has the potential for the treatment of nonalcoholic fatty liver diseases including fatty liver and hepatic fibrosis. ASB14780 significantly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA and TGFb1 in the liver, as well as the expression of monocyte/macrophage markers. Synonyms: ASB14780; ASB 14780; ASB-14780; 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol; 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol. Grades: 99%. CAS No. 1069046-00-9. Molecular formula: C31H27NO3.C4H11NO3. Mole weight: 582.69. | |
Avarol Quick inquiry Where to buy Suppliers range | Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Group: Biochemicals. Alternative Names: NSC 306951. Grades: Highly Purified. CAS No. 55303-98-5. Pack Sizes: 1mg. Molecular Formula: C21H30O2. US Biological Life Sciences. | Worldwide |
AX 048 Quick inquiry Where to buy Suppliers range | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grades: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
Bisindolylmaleimide VIII acetate Quick inquiry Where to buy Suppliers range | Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor with IC50 of 158 nM for rat brain that acts at the ATP binding site. Bis VIII has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C γ1. BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 of 600 nM. Synonyms: BIM VIII; Ro 31-7549. Grades: ≥98%. CAS No. 138516-31-1. Molecular formula: C24H22N4O2·C2H4O2. Mole weight: 458.5. | |
BMS-229724 Quick inquiry Where to buy Suppliers range | BMS-229724 is a selective tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2) in that it did not inhibit secreted phospholipase A2 in vitro, nor phospholipase C and phospholipase D in cells. BMS-22972 acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. Synonyms: 4-[4-[2-[2-[bis (4-chlorophenyl) methoxy]ethylsulfonyl]ethoxy]phenyl]-1, 1, 1-trifluorobutan-2-one; 4- (4- (2- (2- (bis (4-chlorophenyl) methoxy) ethylsulfonyl) ethoxy) phenyl) -1, 1, 1-trifluoro-2-butanone; BMS-229724; BMS 229724; BMS229724; 42AD6D8ECA; SCHEMBL3304414; LS-46643; UNII-42AD6D8ECA. Grades: >98%. CAS No. 221914-85-8. Molecular formula: C27H25Cl2F3O5S. Mole weight: 589.45. | |
Bromoenol lactone Quick inquiry Where to buy Suppliers range | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
BW-B 70C Quick inquiry Where to buy Suppliers range | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
C16 Ceramide-1-phosphate (d18:1/16:0) ammonium salt Quick inquiry Where to buy Suppliers range | C16 Ceramide-1-phosphate (C16 C1P) is one of the main forms of C1P found in cells. It is created by phosphorylation of by ceramide kinase. It activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells. Synonyms: C16 C1P; C16 Ceramide-1-phosphate; N-(hexadecanoyl)-sphing-4-enine-1-phosphate; CerP(d18:1/16:0). Grades: ≥98%. CAS No. 1246303-22-9. Molecular formula: C34H71N2O6P. Mole weight: 634.91. | |
C24:1 Ceramide (Nervonic Ceramide) Quick inquiry Where to buy Suppliers range | Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Group: Biochemicals. Alternative Names: Nervonic Ceramide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
C24 Ceramide (Lignoceric Ceramide) Quick inquiry Where to buy Suppliers range | Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Group: Biochemicals. Alternative Names: Lignoceric Ceramide. Grades: Highly Purified. CAS No. 34435-05-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Caloporoside Quick inquiry Where to buy Suppliers range | Caloporoside is a phospholipase C inhibitor produced by Caloporus dichrous. It has only weak antifungal and bacterial activity, and has the effect of selectively inhibiting phospholipase C. Synonyms: 2-O-Acetyl-5-O-(2-O-acetylhexopyranosyl)-2-C-[17-(2-carboxy-3-hydroxyphenyl)heptadecan-2-yl]hexonic acid; D-Mannonic acid, 5-O-(2-O-acetyl-beta-D-mannopyranosyl)-, 16-(2-carboxy-3-hydroxyphenyl)-1-methylhexadecyl ester, 2-acetate, (R)-. CAS No. 160471-36-3. Molecular formula: C40H64O17. Mole weight: 816.92. | |
Calphostin C (UCN 1028C, PKF115-584, Cal-C) Quick inquiry Where to buy Suppliers range | Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion. Source:Cladosporium cladosporioides sp. Group: Biochemicals. Grades: Highly Purified. CAS No. 121263-19-2. Pack Sizes: 100ug, 1mg. Molecular Formula: C44H38O14 , Molecular Weight: ~790.8. US Biological Life Sciences. | Worldwide |
CAY10502 Quick inquiry Where to buy Suppliers range | Phospholipases A2 (PLA2s) are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule. It catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively. Synonyms: CAY10502; CAY-10502. Grades: ≥98% (mixture of isomers). CAS No. 888320-29-4. Molecular formula: C30H37NO7. Mole weight: 523.6. | |
CAY10590 Quick inquiry Where to buy Suppliers range | Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. There are three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2). CAY10590 is a selective and potent inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2. Synonyms: CAY 10590; CAY-10590. Grades: ≥98%. CAS No. 1101136-50-8. Molecular formula: C21H33NO3. Mole weight: 347.5. | |
CAY10594 Quick inquiry Where to buy Suppliers range | Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. There are two mammalian isoforms of PLD, which are PLD1 and PLD2. CAY10594 is a potent phospholipase D2 inhibitor (PLD2), which also prevents the invasive migration of breast cancer cells. It ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Synonyms: CAY 10594; CAY-10594. Grades: ≥98%. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.5. | |
CAY10650 Quick inquiry Where to buy Suppliers range | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grades: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
CDIBA Quick inquiry Where to buy Suppliers range | CDIBA is a potent and selective cytosolic phospholipase A2 (cPLA2) inhibitor. Synonyms: 4-[2-(1-benzhydryl-5-chloro-2-methylindol-3-yl)ethoxy]benzoic acid. Grades: 99%. CAS No. 479422-22-5. Molecular formula: C31H26ClNO3. Mole weight: 496. | |
Cgp-33304 Quick inquiry Where to buy Suppliers range | Cgp-33304 is a dual phospholipase A2 inhibiting agent and leukotriene receptor antagonists. It may prevent hypoxia secondary to leukotriene induced bronchoconstriction in shock states. It has potential to be an useful therapeutic agent in acute ischemic disorders including traumatic shock. Uses: Cgp-33304 has potential to be an useful therapeutic agent in acute ischemic disorders including traumatic shock. Synonyms: Cgp 33304; Cgp33304; Cgp-33304; 1H-Tetrazole-5-carboxamide, N-(5-(3-(4-acetyl-3-hydroxy-2-propylphenox y)propoxy)-4-bromo-2-methylphenyl)-, monosodium salt;CGP33304;N-(3-(3-(4-Acetyl-3-hydroxy-2-n-propylphenoxy)propoxy)-4-bromo-6-methylphenyl)-1H-tetrazole-5-carboxamide sodium;Sodium 5-((5-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-bromo-2-methylphenyl)carbamoyl)tetrazol-1-ide. Grades: >98%. CAS No. 111130-14-4. Molecular formula: C23H25BrN5NaO5. Mole weight: 554.38. | |
Cgp-35949 Quick inquiry Where to buy Suppliers range | Cgp-35949 is an LTD4 antagonist which has phospholipase inhibitory activity. It represents a new approach to the treatment of asthma. Uses: Cgp-35949 represents a new approach to the treatment of asthma. Synonyms: Cgp 35949; Cgp-35949; Cgp35949; 1H-Tetrazole-5-carboxamide, N-(5-(3-(4-acetyl-3-hydroxy-2-propylphenox y)propoxy)-4-chloro-2-methylphenyl)-, monosodium salt;CGP35949;N-(5-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-chloro-2-methylphenyl)-1H-tetrazole-5-carboxamide monosodium salt;Sodium N-[5-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-chloro-2-methylphenyl]-1,2,3-triaza-4-azanidacyclopenta-2,5-diene-5-carboxamide;Sodium 5-((5-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-chloro-2-methylphenyl)carbamoyl)tetrazol-1-ide. Grades: >98%. CAS No. 111130-13-3. Molecular formula: C23H25ClN5NaO5. Mole weight: 509.92. | |
Cinnamycin Quick inquiry Where to buy Suppliers range | It is an antibiotic produced by several species of streptoverticillium. It is a potent indirect inhibitor of phospholipase A2 by specifically sequestering phosphatidylethanolamine (PE). It has antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells. It is also an immunopotentiator. Synonyms: Lanthiopeptin; Ro 09-0198; NSC 71936; Antibiotic NSC-71936; Antibiotic Ro 09-0198; L-cysteinyl-L-arginyl-L-glutaminyl-D-cysteinyl-L-cysteinyl-3-aminoalanyl-L-phenylalanylglycyl-L-prolyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-L-valyl-L-cysteinyl-(3R)-3-hydroxy-L-a-aspartylglycyl-L-asparaginyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-lysine, cyclic (1?18), (4?14), (5?11)-tris(thioether), cyclic (6?19)-imine. Grades: >98% by HPLC. CAS No. 110655-58-8. Molecular formula: C89H125N25O25S3. Mole weight: 2041.29. | |
Compound 48/80 hydrochloride Quick inquiry Where to buy Suppliers range | Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells. Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C. Synonyms: 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine trihydrochloride. Grades: ≥95%. CAS No. 848035-21-2. Molecular formula: C32H45N3O3·3HCl. Mole weight: 629.1. | |
CRM-51005 Quick inquiry Where to buy Suppliers range | It is a phospholipase C (PLC) inhibitor originally isolated from fungal MT51005. Synonyms: Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-((1E)-1-methyl-1-pentenyl)-; Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-(1-methyl-1-pentenyl)-, (E)-; 3-ethyl-6-[(E)-hex-2-en-2-yl]-2,4-dihydroxybenzaldehyde. CAS No. 203051-01-8. Molecular formula: C15H20O3. Mole weight: 248.32. | |
Cyclooctatin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Sreptomyces melanosporofaciens M1614-43F2. It can inhibit the hemolysis phospholipase [EC 3.1.1.5] (Lyso-PL) activity. Terpentecin as substrates, it inhibits Lyso-PL, PL-A2, PL-C and PL-D with IC50 of 2.9 μg/mL, 65.0 μg/mL, 70.0 μg/mL and >100 μg/mL, respectively. Ki is 4.8 X 10-6 mol/L. Synonyms: Dicyclopenta(a,d)cyclooctene-3,4-diol,1,2,3,3a,4,5,7,8,9,9a,10,10a-dodecahydro-4,9a-dimethyl-1-(hydroxymethyl)-7-(1-methylethyl)-; 1-(Hydroxymethyl)-7-isopropyl-4, 9a-dimethyl-1, 2, 3, 3a, 4, 5, 7, 8, 9, 9a, 10, 10a-dodecahydrodicyclopenta[a, d]cyclooctene-3, 4-diol. CAS No. 139552-97-9. Molecular formula: C20H34O3. Mole weight: 322.49. | |
D609 Quick inquiry Where to buy Suppliers range | D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor and is antiviral and antitumor agent. It suppresses LPS- and IFNγ-induced NO production and blocks oxidative glutamate toxicity in nerve cells. Synonyms: D-609; D 609; D609; D-609 free. Grades: >98%. CAS No. 83373-60-8. Molecular formula: C11H15KOS2. Mole weight: 266.46. | |
Darapladib Quick inquiry Where to buy Suppliers range | Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Synonyms: SB-480848; SB 480848; SB480848; Darapladib. Grades: >98%. CAS No. 356057-34-6. Molecular formula: C36H38F4N4O2S. Mole weight: 666.77. | |
des-His1-[Glu9]-Glucagon (1-29) amide Quick inquiry Where to buy Suppliers range | A glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes) that displays no agonist activity. It binds to glucagon receptors to stimulate breakdown of inositol phospholipids by phospholipase C. It was shown to potentiate glucose-stimulated pancreatic insulin release in vitro. It blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats. Synonyms: (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine); H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2; L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threoninamide. Grades: ≥95%. CAS No. 110084-95-2. Molecular formula: C148H221N41O47S. Mole weight: 3358.68. | |
[Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt Quick inquiry Where to buy Suppliers range | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grades: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
D-myo-Inositol-1,4,5-triphosphate potassium salt Quick inquiry Where to buy Suppliers range | D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium. Synonyms: D-MYO-INOSITOL 1,4,5-TRIPHOSPHATE TRIPOTASSIUM SALT; tripotassium; [ (1R, 2S, 3R, 4R, 5S, 6R)-2, 3, 5-trihydroxy-4, 6-bis[[hydroxy (oxido)phosphoryl]oxy]cyclohexyl] hydrogen phosphate; D-Myo-inositol-1,2,5-tris(dihydrogen phosphate), tripotassium salt; PD020902; D-myo-Inositol 1,4,5-triphosphate tripotassium salt, >=95% (HPLC). Grades: ≥98%. CAS No. 141611-11-2. Molecular formula: C6H12O15P3·3K. Mole weight: 534.4. | |
D-myo-Inositol-1,4,5-triphosphate sodium salt Quick inquiry Where to buy Suppliers range | D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium. Grades: ≥98%. CAS No. 141611-10-1. Molecular formula: C6H12O15P3·3Na. Mole weight: 486. | |
D-myo-Inositol-2,4,5-triphosphate sodium salt Quick inquiry Where to buy Suppliers range | D-myo-Inositol-2,4,5-triphosphate sodium salt is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3. Synonyms: Ins(2,4,5)P3 sodium salt; 2,4,5-IP3 sodium salt; D-myo-inositol-2,4,5-tris(hydrogen phosphate), trisodium salt. Grades: ≥98%. Molecular formula: C6H12O15P3·3Na. Mole weight: 486. | |
Duramycin B Quick inquiry Where to buy Suppliers range | Duramycins B is a new lanthionine containing antibiotic, has been isolated from Streptoverticillium strain R2075. Duramycins B is a potent inhibitor of human phospholipase A2. It exhibits only a weak antibacterial activity against B.subtilis, and does not display antimicrobial activity against S.aureus, S.mitis, E.coli, K.pneumoniae, P.vulgaris and C.albicans. Grades: ≥98%. CAS No. 132246-31-2. Molecular formula: C86H127N25O25S3. Mole weight: 2007.27. | |
Duramycin C Quick inquiry Where to buy Suppliers range | Duramycin C is a new lanthionine containing antibiotic, has been isolated from Streptomyces griseoluteus (R2107). Duramycin C is a potent inhibitor of human phospholipase A2. It exhibits only a weak antibacterial activity against B.subtilis, and does not display antimicrobial activity against S.aureus, S.mitis, E.coli, K.pneumoniae, P.vulgaris and C.albicans. Grades: ≥98%. CAS No. 132268-38-3. Molecular formula: C82H115N23O27S3. Mole weight: 1951.12. | |
EA4 Quick inquiry Where to buy Suppliers range | EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grades: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8. | |
Edelfosine Quick inquiry Where to buy Suppliers range | Edelfosine, an orally administered antileishmanial drug, has anti-metastasis effect in experimental tumors. Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. Uses: Phosphodiesterase inhibitors. Synonyms: ALP; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-OMe; ET 18-OCH3; rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine; NSC-324368; (±)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium hydroxide inner salt 4-oxide. Grades: ≥95%. CAS No. 70641-51-9. Molecular formula: C27H58NO6P. Mole weight: 523.73. | |
Eicosatetraynoic Acid Quick inquiry Where to buy Suppliers range | ETYA is a nonspecific and cell permeable inhibitor of cyclooxygenases and lipoxygenases. ETYA inhibits phospholipase A2 (PLA2), cytochrome P-450, cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase in whole cells. Synonyms: ETYA; 5,8,11,14-eicosatetraynoic acid; Octadehydroarachidonic acid. Grades: ≥98%. CAS No. 1191-85-1. Molecular formula: C20H24O2. Mole weight: 296.4. | |
Elaidamide Quick inquiry Where to buy Suppliers range | Elaidamide has been found in the cerebrospinal fluid of sleep-deprived cats. Elaidamide is a fatty acid amide that inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM) and porcine pancreatic and human synovial phospholipase A2 (PLA2). Uses: Food additives. Synonyms: Elaidoylamide; (E)-9,10-Octadecenamide; 9E-octadecenamide. Grades: ≥95%. CAS No. 4303-70-2. Molecular formula: C18H35NO. Mole weight: 281.5. | |
Endothelin 1, human, porcine Quick inquiry Where to buy Suppliers range | Endothelin-1 is a 21 amino acid polypeptide with effective vasoconstriction. Activates phospholipase C in fibroblasts expressing ETA receptors. Endothelin-1 autocrine and paracrine signal transduction regulates cell proliferation, apoptosis, migration, and epithelial to mesenchymal transition, suggesting its role in cancer. Uses: Peptide Inhibitors. CAS No. 117399-94-7. Product ID: R1818. | |
Ethyl arachidonate Quick inquiry Where to buy Suppliers range | Arachidonic acid (AA) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. Uses: Arachidonic acid (aa) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. phospholipase a2 releases aa from the membrane phospholipids in response to inflammation. Synonyms: Arachidonic acid ethyl ester. Grades: 95%. CAS No. 1808-26-0. Molecular formula: C22H36O2. Mole weight: 332.52. | |
FIPI Quick inquiry Where to buy Suppliers range | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Synonyms: 5-Fluoro-2-Indolyl des-Chlorohalopemide; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide; 5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide. Grades: >98 %. CAS No. 939055-18-2. Molecular formula: C23H24FN5O2. Mole weight: 421.47. | |
FIPI hydrochloride Quick inquiry Where to buy Suppliers range | FIPI hydrochloride is an inhibitor of phospholipase D (PLD) (IC50 values of 20-25 nM for both PLD1 and PLD2), which is an enzyme catalyzing the hydrolysis of phosphatidylcholine to form phosphatidic acid. FIPI blocks in vivo phosphatidic acid (PA) production with subnanomolar potency. FIPI is a candidate therapeutic for autoimmunity and cancer metastasis. Uses: Potential treatment of autoimmunity and cancer metastasis. Synonyms: AOB33782; AKOS024457709; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride; 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1781834-93-2. Molecular formula: C23H24FN5O2.HCl. Mole weight: 457.93. |