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| Product | Description | |
|---|---|---|
| PI-103 | PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Synonyms: 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol; PI103; PI-103; PI 103. Grades: >98%. CAS No. 371935-74-9. Molecular formula: C19H16N4O3. Mole weight: 348.362. |  |
| PI-103 | PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PI103; PI-103; PI 103. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 371935-74-9. Molecular formula: C19H17ClN4O3. Mole weight: 384.82. Purity: >98%. IUPACName: 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol. Canonical SMILES: OC1=CC=CC(C2=NC(N3CCOCC3)=C(OC4=NC=CC=C45)C5=N2)=C1. Product ID: ACM371935749. Alfa Chemistry ISO 9001:2015 Certified. Categories: PS-100 Karachi East-IV. |  |
| PI-103 (3-(4-(4-Morpholinyl)pyrido[3, 2:4, 5]furo[3, 2-d]pyrimidin-2-yl)phenol) | A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2 β, p110δ, mTORC2, p110 β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo. Group: Biochemicals. Alternative Names: 3-(4-(4-Morpholinyl)pyrido[3, 2:4, 5]furo[3, 2-d]pyrimidin-2-yl)phenol. Grades: Highly Purified. CAS No. 371935-74-9. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| PI-103 - CAS 371935-74-9 | A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR. Group: Fluorescence/luminescence spectroscopy. |  |
| PI-103 Hydrochloride | A selective class I PI3K inhibitor; it inhibits PI3K p110 isoforms, mTOC1 and also DNA-PK; a valuable tool compound. Synonyms: PI 103 hydrochloride; PI103 hydrochloride. Grades: >98%. CAS No. 371935-79-4. Molecular formula: C19H17ClN4O3. Mole weight: 384.82. | |
| GDC-0941, Free Base, PI3K Inhibitor | GDC-0941 is a potent inhibitor of p110a and p110d (IC?? = 3nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer." J. Med. Chem. 51: 5522-5532 (2008).GDC-0941 inhibited the growth of >70% ...I., et al. "Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941." Mol. Cancer Ther. 8: 1725-1738 (2009). Group: Biochemicals. Alternative Names: 2- (1H-indazol-4-yl) -6- ( (4- (methylsulfonyl) piperazin-1-yl) methyl) -4-morpholinothieno[3, 2-d]pyrimidine; 4-[2- (1H-Indazol-4-yl) -6-[[4- (methylsulfonyl) piperazin-1-yl]methyl]thieno[3, 2-d]pyrimidin-4-yl]morpholine; GDC 0941; GDC 941; GNE 0941; Pictilisib; Pictrelisib. Grades: Highly Purified. CAS No. 957054-30-7. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 513.64. US Biological Life Sciences. | Worldwide |
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