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Product
Picropodophyllotoxin ?96% (HPLC), powder. Group: Fluorescence/luminescence spectroscopychiral moleculesenzyme activators, inhibitors & substrates. Alternative Names: Picropodophyllin (6CI,7CI,8CI), Picropodophyllotoxin, Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5?,5a?,8a?,9?)]-, (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, AXL 1717, NSC 36407, (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)-. Alfa Chemistry Analytical Products
Picropodophyllotoxin Picropodophyllotoxin. Group: Biochemicals. Grades: Purified. CAS No. 477-47-4. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 5
Worldwide
picropodophyllin Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. Synonyms: AXL1717; AX-L1717; AXL 1717; PPP; Picropodophyllotoxin. Grades: >98%. CAS No. 477-47-4. Molecular formula: C22H22O8. Mole weight: 414.41. BOC Sciences 10

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