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| Product | Description | |
|---|---|---|
| Pifithrin-alpha (cyclic) hydrobromide (2- (4- methyl phenyl) imidazo-5, 6, 7, 8-tetra hydrobenzothiazole. HBr) | Stable analog of pifithrin-alpha. p53 inhibitor. Group: Biochemicals. Alternative Names: 2- (4- methyl phenyl) imidazo-5, 6, 7, 8-tetra hydrobenzothiazole. HBr. Grades: Highly Purified. CAS No. 60477-34-1. Pack Sizes: 5mg, 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Pifithrin-α hydrobromide | Pifithrin-α hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 63208-82-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Pifithrin-α hydrobromide | Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pifithrin hydrobromide; PFTα hydrobromide. CAS No. 63208-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15484. |  |
| Pifithrin-α hydrobromide | Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Synonyms: Pifithrin-alpha; Pifithrin alpha; PFT-alpha; PFTalpha; PFT alpha. Grades: >98%. CAS No. 63208-82-2. Molecular formula: C16H18N2OS·HBr. Mole weight: 367.3. |  |
| Pifithrin-alpha hydrobromide (1- (4-Methylphenyl) -2- (4, 5, 6, 7-tetrahydro-2-imino-3 (2H) -benzothiazolyl) ethanone. HBr) | p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor. Group: Biochemicals. Alternative Names: 1- (4-Methylphenyl) -2- (4, 5, 6, 7-tetrahydro-2-imino-3 (2H) -benzothiazolyl) ethanone. HBr. Grades: Highly Purified. CAS No. 63208-82-2. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C16H18N2OS. HBr, Method for Determining. US Biological Life Sciences. | Worldwide |
| Pifithrin alpha Hydrobromide ([1- (4-Methylphenyl) -2- (4, 5, 6, 7-tetrahydro-2-imino-3 (2H) -benzothiazolyl) ethanone HBr]) | A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Group: Biochemicals. Alternative Names: [1- (4-Methylphenyl) -2- (4, 5, 6, 7-tetrahydro-2-imino-3 (2H) -benzothiazolyl) ethanone HBr]. Grades: Highly Purified. CAS No. 63208-82-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Pifithrin-Alpha, P-Nitro | Pifithrin-Alpha, P-Nitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone;hydrobromide. Appearance: Crystalline solid. CAS No. 389850-21-9. Molecular formula: C15H16BrN3O3S. Mole weight: 398.27. Purity: 0.95. Product ID: ACM389850219. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Pifithrin-β | Pifithrin-β is a potent p53 inhibitor (IC50=23 uM) in an antiproliferative, showing a conformation similar to those of the prototypical AhR ligand β-naphthoflavone. Uses: A cell-permeable and very stable analog of pifithrin-α with similar biological function, but with reduced cytotoxicity. Synonyms: Cyclic Pifithrin-α; 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole. Grades: ≥98%. CAS No. 60477-34-1. Molecular formula: C16H16N2S.HBr. Mole weight: 349.29. | |
| Pifithrin-β hydrobromide | Pifithrin-β hydrobromide is a reversible inhibitor of p53-dependent transcription and apoptosis, inhibits the growth of the cancer cell lines IGROV-1 (IC50 = 23 μM). Uses: Inhibits the growth of the cancer cell lines igrov-1, a2780, and hct116. Synonyms: Cyclic Pifithrin-alpha Hydrobromide; 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide. Grades: ≥98%. CAS No. 511296-88-1. Molecular formula: C16H17BrN2S. Mole weight: 349.29. | |
| Pifithrin-β hydrobromide | Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC 50 of 23 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide. CAS No. 511296-88-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16702A. | |
| Pifithrin-mu | Pifithrin-mu is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL (Kd = 0.82 mM) and Bcl-2 (Kd = 0.80 mM). Pifithrin-mu enhances reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) via silencing p53. Synonyms: Pifithrin-μ; phenylethynesulfonamide; Pifithrin-micro; NSC 303580. Grades: >98%. CAS No. 64984-31-2. Molecular formula: C8H7NO2S. Mole weight: 181.21. | |
| Pifithrin-u | Pifithrin-u. Group: Biochemicals. Grades: Purified. CAS No. 64984-31-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Cyclic Pifithrin-α hydrobromide | Cyclic analog of pifithrin-α , a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01uM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.CAS Number:511296-88-1. Group: Biochemicals. Alternative Names: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide, Pifithrin- β. Grades: Highly Purified. CAS No. 511296-88-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C16H16N2S.HBr, Molecular Weight: 349.29. US Biological Life Sciences. | Worldwide |
| Phenylethynsulfonic Acid Amide (Phenyl-ethynesulfonic Acid Amide, Pifithrin-u, PFTu) | A small molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Group: Biochemicals. Alternative Names: Phenyl-ethynesulfonic Acid Amide, Pifithrin-u, PFTu. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| p-nitro-Cyclic Pifithrin-α | p-nitro-Cyclic PFT-α is a cell-permeable p53 inhibitor that prevents p53 posttranscriptional activity. Synonyms: Cyclic pifithrin-α-p-nitro; p-nitro-Cyclic PFT-&alpha. Grades: ≥95%. CAS No. 60477-38-5. Molecular formula: C15H13N3O2S. Mole weight: 299.3. | |
| p-nitro-Pifithrin-α | p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 389850-21-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130437. | |
| p-nitro-Pifithrin-α | p-nitro-Pifithrin-α is a cell-permeable p53 inhibitor. It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-&alpha. It also suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet. Synonyms: p-nitro-PFT-α; 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone hydrobromide. Grades: ≥95%. CAS No. 389850-21-9. Molecular formula: C15H15N3O3S·HBr. Mole weight: 398.3. | |
| Phenylethynsulfonic acid amide | Phenylethynsulfonic acid amide. Group: Biochemicals. Alternative Names: Phenyl-ethynesulfonic acid amide; Pifithrin-mu; PFT-mu. Grades: Highly Purified. CAS No. 64984-31-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C8H7NO2S. US Biological Life Sciences. | Worldwide |
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