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| Product | Description | |
|---|---|---|
| Pilaralisib | Pilaralisib, also known as XL147, is a methylbenzenesulfonamide derivative that reversibly inhibits class I PI3Ks (IC50s = 39, 36, 23, and 383 nM for p110α, δ, γ, and β, respectively), with potential antineoplastic activity. Synonyms: 2-amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide.; XL147; XL 147; XL-147; SAR245408; SAR-245408; SAR 245408; Pilaralisib. CAS No. 934526-89-3. Molecular formula: C25H25ClN6O4S. Mole weight: 541.02. |  |
| Pilaralisib | Pilaralisib (XL147; SAR245408) is a potent and highly selective class I PI3K s inhibitor with IC 50 s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3K&delta. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XL-147; SAR245408. CAS No. 934526-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16526. |  |
| XL147 | Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule, targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and inhibiting the activation of the PI3K signaling pathway. Uses: Pilaralisib has potential antineoplastic activity. Synonyms: XL147-II; XL147 II; XL147II; XL147 derivative II; XL147derivativeII; XL147-derivative-II; N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide;SAR245408;N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide;PI3K inhibitorX. Grades: >99%. CAS No. 956958-53-5. Molecular formula: C21H16N6O2S2. Mole weight: 448.52. | |
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