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| Product | Description | |
|---|---|---|
| PIM-1 Inhibitor 2 | PIM-1 Inhibitor 2, a pyrimidinyl-benzisoxazolo compound, is a potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region. Synonyms: 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine; PIMi II. Grades: ≥98% by HPLC. CAS No. 477845-12-8. Molecular formula: C17H11ClN4O. Mole weight: 322.75. |  |
| PIM-1 Inhibitor 2 | PIM-1 Inhibitor 2. Group: Biochemicals. Grades: Purified. CAS No. 477845-12-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| CX-6258 hydrochloride hydrate | CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC 50 s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1353858-99-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18095A. |  |
| Hispidulin | Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC 50 of 2.71 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Dinatin. CAS No. 1447-88-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1950. | |
| LKB1/AAK1 dual inhibitor | LKB1/AAK1 dual inhibitor is an effective inhibitor against multi-kinase especially Pim-1 kinase, which has been newly found to be highly expressed in sorts of isolated human cancer cells. Kd: 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1. Synonyms: LKB1/AAK1 dual inhibitor; MDK-2275; MDK 2275; MDK2275; Pim1/AKK1-IN-1; N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide; Pim1 AKK1-IN-1. Grades: 98%. CAS No. 1093222-27-5. Molecular formula: C20H13N5O. Mole weight: 339.35. | |
| LY294002 | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. | Worldwide |
| M-110 | M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC 50 =47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC 50 s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC 50 s of 0.6 to 0.9 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1395048-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12830. | |
| PIM-Kinase Inhibitor IX, SGI-1776 (N- ( (1-Methylpiperidin-4-yl) methyl) -3- (3- (trifluoromethoxy) phenyl) imidazo[1, 2-b]pyridazin-6-amine, 2H2SO4) | A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50=7, 363, 69, 44 and 34nM, respectively) with moderate (40% inhibition at 1uM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O; 2H?SO?, Molecular Weight: 601.6. US Biological Life Sciences. | Worldwide |
| Quercetagetin | Quercetagetin (6-Hydroxyquercetin) is a flavonoid [1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor ( IC 50 , 0.34 μM) [2]. Anti-inflammatory and anticancer properties. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Hydroxyquercetin. CAS No. 90-18-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N4149. | |
| Quercetagetin | Quercetagetin is a flavonol that acts as an inhibitor of Pim-1 with IC50 value of 0.34 μM. It is derived from quercetin and exhibits antioxidant and antiviral effects. Uses: Enzyme inhibitors. Synonyms: 6-hydroxy Quercetin; NSC 115916; 3,3',4',5,6,7-Hexahydroxyflavone; 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxychromen-4-one. Grades: ≥98%. CAS No. 90-18-6. Molecular formula: C15H10O8. Mole weight: 318.2. | |
| R8-T198wt | R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase. It inhibits Pim-1 phosphorylation of p27Kip1 and Bad, and induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt is possible that this peptide can also inhibit other kinases of the Pim family, such as Pim-2 and Pim-3, because not only Pim-1 but also Pim-2 and Pim-3 can directly phosphorylate p27Kip1 at the Thr198 residue. Synonyms: H-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr-OH. Grades: >95%. CAS No. 2305815-72-7. Molecular formula: C111H211N59O26S. Mole weight: 2820.33. | |
| SMI-4a | SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM against Pim-1 and 100 nM against Pim-2) with little or no activity against a panel of 58 other kin. Synonyms: SMI-4a; SMI 4a; SMI4a; (5E)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dioneTCS-PIM-1-4aMS-1740; MS 1740; MS1740327033-36-35-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione. CAS No. 327033-36-3. Molecular formula: C11H6F3NO2S. Mole weight: 273.20. | |
| SMI-4a (5E/Z) -[[3- (Trifluoromethyl) phenyl]methylene]-2, 4-thiazolidinedione) | A selective, ATP-competitive inhibitor Pim-1 (IC50=21nm) and Pim-2 (IC50=100nm) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TCS PIM-1 1 | TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TCS PIM-1 1; SC204330; SC-204330; SC 204330. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 491871-58-0. Molecular formula: C18H11BrN2O2. Mole weight: 367.2. Purity: >98%. IUPACName: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone. Canonical SMILES: O=C1C(C#N)=C(C2=CC=CC=C2)C=C(C3=C(O)C=CC(Br)=C3)N1. Product ID: ACM491871580. Alfa Chemistry ISO 9001:2015 Certified. Categories: 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile. |  |
| TCS PIM-1 1 | TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displaying good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). Synonyms: TCS PIM-1 1; 491871-58-0; 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile; 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile; CHEMBL391586; CHEBI:86453; 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone; C18H11BrN2O2; 2obj; MFCD00276275; PIM1i; pyridone-based compound, 1; TCS PIM-11; TCS-PIM-1-1; SCHEMBL15129618; BDBM26673; EX-A308; HMS3229J17; HMS3742G19; BCP15861; 6-(5-bromo-2-hydroxy-phenyl)-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile; AKOS024457365; CCG-101294; CS-2043; DB08705; AC-35434; AS-16824; HY-18086; FT-0700318; S1050; A871835; Q27097891; SC 204330; SC-204330; SC204330; 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone; 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-pyridine-3-carbonitrile; VRV. CAS No. 491871-58-0. Molecular formula: C18H11BrN2O2. Mole weight: 367.202. | |
| Tp3654 | Tp3654 is an inhibitor of Pim-1 and Pim-3 that has the potential to treat prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis. Uses: Tp3654 is an inhibitor of pim-1 and pim-3. Synonyms: TP-3654; TP3654; TP 3654; SCHEMBL102560; CS-6293; HY-101126; CS 6293; HY 101126; CS6293; HY101126; 2-[4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexyl]propan-2-ol. Grades: ≥98%. CAS No. 1361951-15-6. Molecular formula: C22H25F3N4O. Mole weight: 418.464. | |
| TP-3654 | TP-3654 is a second-generation Pim kinase inhibitor with K i values of 5 and 42 nM for Pim-1 and Pim-3, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1361951-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101126. | |
| (Z)-SMI-4a | (Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. Synonyms: SMI-4a; SMI4a; SMI 4a; TCS PIM-1 4a. CAS No. 438190-29-5. Molecular formula: C11H6F3NO2S. Mole weight: 273.229. | |
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