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| Product | Description | |
|---|---|---|
| PIM447 | PIM447 (LGH447) is a potent, orally available, and selective pan- PIM kinase inhibitor, with K i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LGH447. CAS No. 1210608-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-19322. |  |
| PIM447 | This active molecular is a potent PIM 1, 2, and 3 kinase inhibitor under the development of Novartis. In vivo, PIM447 reduces the tumor burden and also preventes tumor-associated bone loss in a disseminated murine model of human myeloma. In vitro, it inhibits osteoclast formation and resorption. Moreover, it increases osteoblast activity and mineralization. In May 2016, Novartis completed a phase I trial for Multiple myeloma (Second-line treatment or greater) in Japan. Uses: Multiple myeloma. Synonyms: PIM447; PIM 447; PIM-447; LGH-447;N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide. Grades: 98%. CAS No. 1210608-43-7. Molecular formula: C24H23F3N4O. Mole weight: 440.47. |  |
| PIM-447 dihydrochloride | PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan- PIM kinase inhibitor, with K i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LGH447 dihydrochloride. CAS No. 1820565-69-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19322B. | |
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