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| Product | Description | |
|---|---|---|
| Pipendoxifene | Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50=14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50=0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923. In preclinical models, ERA-923 has an improved efficacy and safety compared with tamoxifen. In the combination with temsirolimus, ERA-923 showed excellent anticancer activity in preclinical models. Synonyms: ERA-923; ERA 923; ERA923; 2-(p-Hydroxyphenyl)-3-methyl-1-(p-(2-piperidinoethoxy)benzyl)indol-5-ol. Grades: >98%. CAS No. 198480-55-6. Molecular formula: C29H32N2O3. Mole weight: 456.58. |  |
| Pipendoxifene hydrochloride | Pipendoxifene hydrochloride is the hydrochloride salt of Pipendoxifene, which is a selective estrogen receptor modulator (SERM). Synonyms: 2-(4-hydroxyphenyl)-3-methyl-1-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]indol-5-ol;hydrochloride; Pipendoxifene (hydrochloride). CAS No. 245124-69-0. Molecular formula: C29H33ClN2O3. Mole weight: 493.04. | |
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