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Piperazin-2-one. Group: Biochemicals. Alternative Names: 2-Oxopiperazine. Grades: Highly Purified. CAS No. 5625-67-2. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C4H8N2O. US Biological Life Sciences.
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Piperazin-2-one
Piperazin-2-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 5625-67-2. Pack Sizes: 25 g; 100 g. Product ID: HY-20128.
1-(2,3-Dimethyl-phenyl)-piperazin-2-one
1-(2,3-Dimethyl-phenyl)-piperazin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(2,3-DIMETHYL-PHENYL)-PIPERAZIN-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 907972-44-5. Molecular formula: C12H16N2O. Mole weight: 204.27. Product ID: ACM907972445. Alfa Chemistry ISO 9001:2015 Certified.
1-(2'-Fluoro)ethyl-4-(tert-butyloxycarbonyl)piperazin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(2'-FLUORO)ETHYL-4-(TERT-BUTYLOXYCARBONYL)PIPERAZIN-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 194351-12-7. Molecular formula: C11H19FN2O3. Mole weight: 246.28. Product ID: ACM194351127. Alfa Chemistry ISO 9001:2015 Certified.
1-(3-Aminophenyl)piperazin-2-one
1-(3-Aminophenyl)piperazin-2-one is a versatile reactant used in the preparation of pyrimidine derivatives as KDR inhibitor useful in the treatment of angiogenesis related diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1022128-80-8. Pack Sizes: 25mg, 50mg. Molecular Formula: C10H13N3O, Molecular Weight: 191.23. US Biological Life Sciences.
1-(4-Methoxybenzyl)piperazin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(4-METHOXYBENZYL)PIPERAZIN-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 893747-38-1. Molecular formula: C12H16N2O2. Mole weight: 220.27. Product ID: ACM893747381. Alfa Chemistry ISO 9001:2015 Certified.
1-(4-Methoxy-phenyl)-piperazin-2-one
1-(4-Methoxy-phenyl)-piperazin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(4-METHOXY-PHENYL)-PIPERAZIN-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 215649-82-4. Molecular formula: C11H14N2O2. Mole weight: 206.24. Product ID: ACM215649824. Alfa Chemistry ISO 9001:2015 Certified. Categories: 1-(4-methoxyphenyl)piperazin-2-one.
1-(4-Methylphenyl)piperazin-2-one
1-(4-Methylphenyl)piperazin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-P-TOLYL-PIPERAZIN-2-ONE;1-(4-METHYLPHENYL)PIPERAZIN-2-ONE;OTAVA-BB 1310643. Product Category: Heterocyclic Organic Compound. CAS No. 893748-24-8. Molecular formula: C11H14N2O. Mole weight: 190.24. Product ID: ACM893748248. Alfa Chemistry ISO 9001:2015 Certified.
3-(4-Fluoro-phenyl)-piperazin-2-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 85606-96-8. Molecular formula: C10H11FN2O. Mole weight: 194.21. Product ID: ACM85606968. Alfa Chemistry ISO 9001:2015 Certified. Categories: 3-(4-FLUOROPHENYL)PIPERAZIN-2-ONE.
Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC50=90nM for Nutlin-3a and 13.6uM for Nutlin-3b), p53 pathway activator, and apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 548472-68-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
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1-(2-Fluorophenyl)-2-piperazinone
1-(2-Fluorophenyl)-2-piperazinone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(2-FLUORO-PHENYL)-PIPERAZIN-2-ONE;1-(2-Fluorophenyl)-2-piperazinone. Product Category: Heterocyclic Organic Compound. CAS No. 907972-55-8. Molecular formula: C10H11FN2O. Mole weight: 194.21. Density: 1.225. Product ID: ACM907972558. Alfa Chemistry ISO 9001:2015 Certified.
2-Piperazinone
2-Piperazinone. Group: Biochemicals. Alternative Names: Tetrahydro-2(1H)-pyrazinone; 2-Ketopiperazine; 2-Oxopiperazine; 3-Oxopiperazine; Oxopiperazine; Piperazin-2-one; Piperazine-2-one; NSC 27441. Grades: Highly Purified. CAS No. 5625-67-2. Pack Sizes: 2g. US Biological Life Sciences.
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4-[(2-Aminoethyl)sulfonyl]-piperazinone
4-[(2-Aminoethyl)sulfonyl]-piperazinone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[(2-AMINOETHYL)SULFONYL]-PIPERAZINONE;4-[(2-AMINOETHYL)SULFONYL]-PIPERAZIN-2-ONE HYDROCHLORIDE. Product Category: Heterocyclic Organic Compound. CAS No. 800388-09-4. Molecular formula: C6H13N3O3S. Mole weight: 207.25. Product ID: ACM800388094. Alfa Chemistry ISO 9001:2015 Certified.
This active molecular is a selective dipeptidyl peptidase 4 (DPP4) inhibitor under the development of Dong-A. Evogliptin improves insulin resistance and delays the onset of diabetes. Evogliptin monotherapy improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. In Sep 1st 2016, preclinical trials in Type-2 diabetes mellitus (Combination therapy) in Russia was on-going. In Sep 12th 2016, Phase-I clinical trials in non-alcoholic steatohepatitis (Combination therapy) in USA was on-going. Uses: Type-2 diabetes mellitus. Synonyms: (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one; CHEMBL1779710; UNII-09118300L7; DA-1229; DA 1229; DA1229; 1222102-29-5; Evogliptin [INN]; 1246960-27-9 (HCl). Grade: 98%. CAS No. 1222102-29-5. Molecular formula: C19H26F3N3O3. Mole weight: 401.43.
Piperazinone,1-(2-thiazolyl)-(9ci)
Piperazinone,1-(2-thiazolyl)-(9ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(1,3-THIAZOL-2-YL)PIPERAZIN-2-ONE, 374795-53-6, SureCN1583412, CTK4H8247, 2-Piperazinone,1-(2-thiazolyl)-, 1-(2-THIAZOLYL)-PIPERAZINONE, AKOS006286545, AB37126, AG-F-31739, Piperazinone,1-(2-thiazolyl)- (9CI), 1-THIAZOL-2-YL-PIPERAZIN-2-ONE, PIPERAZINONE, 1-(2-THIAZOLYL)-. Product Category: Heterocyclic Organic Compound. CAS No. 374795-53-6. Molecular formula: C7H9N3OS. Mole weight: 183.23086. Purity: 0.96. IUPACName: 1-(1,3-thiazol-2-yl)piperazin-2-one. Product ID: ACM374795536. Alfa Chemistry ISO 9001:2015 Certified.
Piperazinone,3-[2-(methylthio)ethyl]-(9ci)
Piperazinone,3-[2-(methylthio)ethyl]-(9ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: AG-H-15116, 78551-63-0, PIPERAZINONE, 3-[2-(METHYLTHIO)ETHYL]-, 3-[2-(METHYLSULFANYL)ETHYL]PIPERAZIN-2-ONE, AGN-PC-00MWCZ, SureCN10842286, CTK5E5900, AKOS011636378, AB37175, 2-Piperazinone,3-[2-(methylthio)ethyl]-, 3-[2-(METHYLTHIO)ETHYL]-PIPERAZINONE, Piperazinone,3-[2-(methylthio)ethyl]- (9CI), 3-(2-(METHYLTHIO)ETHYL)PIPERAZIN-2-ONE, 3-(2-METHYLSULFANYL-ETHYL)-PIPERAZIN-2-ONE. Product Category: Heterocyclic Organic Compound. CAS No. 78551-63-0. Molecular formula: C7H14N2OS. Mole weight: 174.26386. Purity: 0.96. IUPACName: 3-(2-methylsulfanylethyl)piperazin-2-one. Canonical SMILES: CSCCC1C(=O)NCCN1. Product ID: ACM78551630. Alfa Chemistry ISO 9001:2015 Certified.
MDM2 Antagonist IV, Nutlin-3a ((-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one)
A cell-permeable and highly potent active enantiomer of Nutlin-3 that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC50=90nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53+/+ MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 675576-98-4. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences.
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