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| Product | Description | |
|---|---|---|
| PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated | The PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| PKC Inhibitor Peptide 19-36 | The PKC Inhibitor Peptide 19-36 controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JAK3/GSK-3b/PKCa Inhibitor (3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII) | A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3b, JAK3, PKCa and PKCth (IC50=3, 8, 13 and 68nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50=1.017, 2.55 and 8.055uM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50=0.525, 1.294 and 0.689uM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 1260181-14-3. Pack Sizes: 5mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 526.5. US Biological Life Sciences. |  Worldwide |
| PKCα (C2-4) Inhibitor Peptide | PKCα (C2-4) inhibitor peptide is an inhibitor of PKC activity in HepG2 cells stimulated with calcium and pancreastatin when applied at 10 μM. Synonyms: Protein Kinase Cα (C2-4) Inhibitor Peptide. Grades: ≥95%. Molecular formula: C47H74N14O17. Mole weight: 1107.2. |  |
| PKCε Inhibitor Peptide | PKC? inhibitor peptide is a synthetic peptide that inhibits the translocation of PKC? to intracellular membranes, blocking activation. PKC? inhibitor peptide is commonly used in cells to evaluate the role of PKC? in various cellular responses. Synonyms: Protein Kinase C? Inhibitor Peptide; ?V1-2. Grades: ≥95%. CAS No. 182683-50-7. Molecular formula: C37H65N9O13. Mole weight: 844. | |
| PKC?II/EGFR Inhibitor - CAS 145915-60-2 | The PKC?II/EGFR Inhibitor, also referenced under CAS 145915-60-2, controls the biological activity of PKC?II/EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC?II Peptide Inhibitor I trifluoroacetate salt | ?95% (HPLC), lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| PKC? Inhibitor - CAS 257879-35-9 | The PKC? Inhibitor, also referenced under CAS 257879-35-9, controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC?/? Pseudosubstrate Inhibitor | The PKC?/? Pseudosubstrate Inhibitor controls the biological activity of PKC?/?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC? Pseudosubstrate Inhibitor, Myristoylated | The PKC? Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC-Theta Inhibitor | PKC-theta inhibitor is a selective PKC-theta inhibitor with IC50 of 12 nM. Synonyms: CHEMBL248183; N4-((4-(Aminomethyl)Cyclohexyl)Methyl)-5-Nitro-N2-(2-(Trifluoromethoxy)Benzyl)Pyrimidine-2,4-Diamine; VC-8650; SCHEMBL3953579. Grades: 98%. CAS No. 736048-65-0. Molecular formula: C20H25F3N6O3. Mole weight: 454.4. | |
| PKCθ Pseudosubstrate Inhibitor | PKCθ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCθ activity. Synonyms: Protein Kinase Cθ Pseudosubstrate Inhibitor. Grades: ≥95%. Molecular formula: C95H165N39O20. Mole weight: 2173.6. | |
| PKC? Translocation Inhibitor Peptide | The PKC? Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC? Translocation Inhibitor Peptide, Negative Control | The PKC? Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKCζ Pseudosubstrate Inhibitor | PKCζ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCζ activity. Synonyms: Protein Kinase Cζ Pseudosubstrate Inhibitor. Grades: ≥95%. CAS No. 799764-07-1. Molecular formula: C76H128N30O16. Mole weight: 1718. | |
| 10Z-Hymenialdisine | 10Z-Hymenialdisine is a pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα, respectively). 10Z-Hymenialdisine inhibits NF-κB activation and suppresses inflammatory gene expression. Synonyms: Hymenialdisine; (Z)-Hymenialdisine; 4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one. Grades: ≥97% by HPLC. CAS No. 82005-12-7. Molecular formula: C11H10BrN5O2. Mole weight: 324.13. | |
| 1,2,3,4-Tetrahydro Staurosporine | Staurosporine derivative for use as isoenzyme PKCα inhibitors and anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 220038-19-7. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione | Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 μM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM. Synonyms: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Grades: > 98 %. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.34. | |
| 3-Chloro-2,5-difluoropyridine | 3-Chloro-2,5-difluoropyridine is an intermediate used to prepare selective protein kinase C ? (PKC?) inhibitors for the treatment of autoimmune diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 851179-00-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H2ClF2N. US Biological Life Sciences. | Worldwide |
| 4',6,7-Trihydroxyisoflavone | 4',6,7-Trihydroxyisoflavone is an isoflavone isolated from the seeds of Glycine max with antioxidant activity. It is also a novel inhibitor of PKCα that suppresses solar UV-induced matrix metalloproteinase 1. Synonyms: Demethyltexasin; 6,7,4'-trihydroxyisoflavone; 6-Hydroxydaidzein; 6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one. Grades: >98%. CAS No. 17817-31-1. Molecular formula: C15H10O5. Mole weight: 270.24. | |
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3ß Inhibitor I, TDZD-8) | Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, also known as TDZD-8, is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK3b (IC50 =2nM). It binds to the active site of GSK3b. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). Group: Biochemicals. Alternative Names: GSK-3ß Inhibitor I, TDZD-8. Grades: Highly Purified. CAS No. 327036-89-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5-Iodotubercidin | 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC 50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 113939; 5-ITu. CAS No. 24386-93-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 25 mg; 50 mg. Product ID: HY-15424. |  |
| 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one | KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. It blocks Akt signalling through the PI3K pathway, and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells. Synonyms: 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one. Grades: ≥95%. CAS No. 1374996-60-7. Molecular formula: C20H8N12O2. Mole weight: 448.4. | |
| a-3 Hydrochloride | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: A3, Hydrochloride, A3 hydrochloride, IN1547, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl, A-3HYDROCHLORIDE, A1980_SIGMA, SCHEMBL3503907, CHEMBL1255867, CTK7E9088, OR0890T, MolPort-001-756-823, CCG-222331, LP01027, NCGC00094317-01, 3B3-053691, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulphonamide hydrochloride, N-(2-AMINOETHYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE, 78957-85-4. Product Category: Inhibitors. CAS No. 78957-85-4. Molecular formula: C12H14Cl2N2O2S. Mole weight: 321.22. Purity: 0.96. IUPACName: N-(2-aminoethyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride. Product ID: ACM78957854. Alfa Chemistry ISO 9001:2015 Certified. |  |
| A-674563 | A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. Synonyms: A674563; A 674563; Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-; (α S) -α - [ [ [5- (3-Methyl-1H-indazol-5-yl) -3-pyridinyl] oxy] methyl] benzeneethanamine; (S)-1-((5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine. Grades: >98%. CAS No. 552325-73-2. Molecular formula: C22H22N4O. Mole weight: 358.44. | |
| A-674563 dihydrochloride | A-674563, an Akt1 inhibitor with a Ki of 11 nM, is moderately potent against PKA and >30-fold selective for Akt1 over PKC. Synonyms: A-674563 2HCl; Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, hydrochloride (1:2), (αS)-; (α S) -α - [ [ [5- (3-Methyl-1H-indazol-5-yl) -3-pyridinyl] oxy] methyl] benzeneethanamine dihydrochloride; (S)-1-((5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride; A 674563 dihydrochloride; A674563 dihydrochloride. Grades: ≥95%. CAS No. 2759293-92-8. Molecular formula: C22H22N4O.2HCl. Mole weight: 431.36. | |
| Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2) | Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58nM (Akt1), 210nM (Akt2) and 2.12uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity. It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. It also prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. Synonyms: AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730. 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-. Grades: >98%. CAS No. 612847-09-3. Molecular formula: C34H29N7O. Mole weight: 551.64. | |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) | A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation / activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| [Ala107]-MBP (104-118) | [Ala107]-MBP (104-118) is a non-competitive inhibitor of PKC with IC50 value of 46-145 mM. It is a synthetic peptide analog of bovine myelin basic protein (MBP). Synonyms: [Ala107]-Myelin Basic Protein (104-118). Grades: >98%. CAS No. 99026-77-4. Molecular formula: C67H104N20O19. Mole weight: 1493.68. | |
| [Ala107]-MBP (104-118) acetate | [Ala107]-MBP (104-118) acetate is a non-competitive inhibitor of PKC with an IC50 value of 46-145 mM. It is a synthetic peptide analog of bovine myelin basic protein (MBP). Synonyms: H-Gly-Lys-Gly-Ala-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH.CH3CO2H; glycyl-L-lysyl-glycyl-L-alanyl-glycyl-L-leucyl-L-seryl-L-leucyl-L-seryl-L-arginyl-L-phenylalanyl-L-seryl-L-tryptophyl-glycyl-L-alanine acetate; [Ala107]-Myelin Basic Protein (104-118) acetate. Grades: ≥95%. Molecular formula: C67H104N20O19.C2H4O2. Mole weight: 1553.74. | |
| [Ala113]-MBP (104-118) | [Ala113]-MBP (104-118) is a non-competitive inhibitor of PKC with IC50 value of 46-145 mM. It is a synthetic peptide analog of bovine myelin basic protein (MBP). Synonyms: [Ala113]-Myelin Basic Protein (104-118). Grades: >98%. CAS No. 99026-78-5. Molecular formula: C67H104N20O19. Mole weight: 1493.68. | |
| [Ala113]-MBP (104-118) acetate | [Ala113]-MBP (104-118) acetate is a non-competitive inhibitor of PKC with IC50 of 28-62 μM. It is a synthetic peptide analog of bovine myelin basic protein (MBP). Synonyms: H-Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Ala-Phe-Ser-Trp-Gly-Ala-OH.CH3CO2H; Glycyl-L-lysyl-glycyl-L-arginyl-glycyl-L-leucyl-L-seryl-L-leucyl-L-seryl-L-alanyl-L-phenylalanyl-L-seryl-L-tryptophyl-glycyl-L-alanine acetic acid; [Ala113]-MBP acetate. Grades: ≥95%. Molecular formula: C69H108N20O21. Mole weight: 1553.74. | |
| Antibiotic K252A (Antibiotic SF 2370) | Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG). Group: Biochemicals. Grades: Highly Purified. CAS No. 99570-78-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Aurothiomalate sodium | Aurothiomalate sodium is a potent and selective oncogenic PKC Ι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 12244-57-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106381. | |
| Autocamtide-2-Related Inhibitory Peptide | Autocamtide-2-related inhibitory peptide is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II) with I50 value of 40 nM. It is selective over PKC, PKA and CaM kinase IV. Synonyms: AIP; [Ala9]-Autocamtide 2. Grades: ≥97% by HPLC. CAS No. 167114-91-2. Molecular formula: C64H116N22O19. Mole weight: 1497.74. | |
| Balanol | It is produced by the strain of Streptomyces sp. Tu 4128. Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA). It is an important target in oncology. Synonyms: 4-(2-Carboxy-6-hydroxybenzoyl)-3,5-dihydroxybenzoic Acid (3R,4R)-Hexahydro-3-[(4-hydroxybenzoyl)amino]-1H-azepin-4-yl Ester; (3R-trans)-Balanol; (-)-Balanol; Azepinostatin; Ophiocordin. Grades: >95%. CAS No. 63590-19-2. Molecular formula: C28H26N2O10. Mole weight: 550.53. | |
| Bisindolylmaleimide I | Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKC&gamma. Bisindolylmaleimide I is also a GSK-3 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF109203X; Go 6850. CAS No. 133052-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13867. | |
| Bisindolylmaleimide I | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF-109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 133052-90-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKC&gamma. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF109203X hydrochloride; Go 6850 hydrochloride. CAS No. 176504-36-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13867A. | |
| Bisindolylmaleimide I hydrochloride | Bisindolylmaleimide I hydrochloride (BMI) is a water soluble form of Bisindolylmaleimide I. It is a staurosporine inspired molecule, which has been shown to display equally potent inhibition. BIM I is a highly selective, cell-permeable, and reversible PKC inhibitor with Ki of 14 nM that is structurally similar to the poorly selective PKC inhibitor staurosporine. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It can inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Synonyms: BIM I; GF109203X; Gö 6850. Grades: ≥98%. CAS No. 176504-36-2. Molecular formula: C25H24N4O2·HCl. Mole weight: 449. | |
| Bisindolylmaleimide I hydrochloride | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF 109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 176504-36-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. HCl. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a general inhibitor of all PKC subtypes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bis II. CAS No. 137592-45-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108604. | |
| Bisindolylmaleimide II | Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells) and an inhibitory effect on PDK1 (IC50 = 14 μM). Synonyms: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. Grades: ≥97% by HPLC. CAS No. 137592-45-1. Molecular formula: C27H26N4O2. Mole weight: 438.52. | |
| Bisindolylmaleimide II | Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA). Group: Biochemicals. Grades: Highly Purified. CAS No. 137592-45-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H26N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide III | Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C) with structural similarity to the nonspecific PKC inhibitor staurosporine. It inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1. Synonyms: BIM III. Grades: ≥98%. CAS No. 137592-43-9. Molecular formula: C23H20N4O2. Mole weight: 384.4. | |
| Bisindolylmaleimide III | Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Grades: Highly Purified. CAS No. 137592-43-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C23H20N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide IV | Cell permeable protein kinase C (PKC) inhibitor. Inhibits also protein kinase A (PKA). Group: Biochemicals. Alternative Names: Ro 31-6233, Arcyriarubin A, BIM IV, 2,3-bis(1H-Indol-3-yl)maleimide. Grades: Highly Purified. CAS No. 119139-23-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C20H13N3O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide IX methanesulfonate | Selective and cell permeable protein kinase C (PKC) inhibitor. Inhibits the stimulation of insulin secretion by glucose. Inhibits T cell activation. Apoptosis inducer. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Transcription inhibitor. Induces TNF receptor family-mediated cell death. Pim-1 kinase inhibitor. Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 138489-18-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H23N5O2S CH4O3S. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide V | Bisindolylmaleimide IV (BIM IV) is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 of 0.10-0.55 μM. It is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 μM. BIM IV also inhibits protein kinase A with IC50 of 2-11.8 μM. Bisindolylmaleimide V is used as a negative control for the PKC (protein kinase C)-inhibitory activity. Synonyms: BIM V; Ro 31-6045. Grades: ≥98%. CAS No. 113963-68-1. Molecular formula: C21H15N3O2. Mole weight: 341.3. | |
| Bisindolylmaleimide V | Negative control for protein kinase C (PKC) inhibitors. S6K inhibitor. Necrosis inhibitor. A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 > 100uM). Blocks the activation of p70s6k/p85s6k in vivo (IC50 = 8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 113963-68-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H15N3O2, Molecular Weight: 341.4. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide VIII acetate | Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor with IC50 of 158 nM for rat brain that acts at the ATP binding site. Bis VIII has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism. BIM VIII does not inhibit the tyrosine phosphorylation or the activation of phospholipase C γ1. BIM VIII inhibits carbachol-evoked noradrenaline release from human SH-SY5Y neuroblastoma cells with an IC50 of 600 nM. Synonyms: BIM VIII; Ro 31-7549. Grades: ≥98%. CAS No. 138516-31-1. Molecular formula: C24H22N4O2·C2H4O2. Mole weight: 458.5. | |
| Bisindolylmaleimide VIII acetate | Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Alternative Names: Ro 31-7549, BIM VIII. Grades: Highly Purified. CAS No. 138516-31-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H22N4O2. CH3COOH. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide X hydrochloride | Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor with IC50 of 15 nM for rat brain PKC. It has also been identified as an inhibitor of Cdk2 with IC50 of 200. It has been used to activate mesenchymal stem cells, which increases the surface expression of homing ligands that bind to intercellular adhesion molecule and target delivery of these cells to sites of inflammation. Uses: Enzyme inhibitors. Synonyms: BIM X; Ro 31-8425. Grades: ≥98%. CAS No. 145317-11-9. Molecular formula: C26H24N4O2·HCl. Mole weight: 461. | |
| Bisindolylmaleimide X hydrochloride | Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils. Group: Biochemicals. Alternative Names: Ro 31-8425, BIM X. Grades: Highly Purified. CAS No. 131848-97-0, 145317-11-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C26H24N4O2 HCl. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide XI hydrochloride | Bisindolylmaleimide XI hydrochloride is a cell-permeable selective inhibitor of PKC displaying a 10-fold greater selectivity for PKCα with IC50 of 9.3 nM. It is a 4-fold greater selectivity for PKC-βI over PKCε with IC50 of 108 nM. It prevents T cell-driven chronic inflammatory responses in several rat models. Synonyms: BIM XI; Ro 31-0432. Grades: ≥98%. CAS No. 145333-02-4. Molecular formula: C28H28N4O2·HCl. Mole weight: 489. | |
| Bisindolylmaleimide XI Hydrochloride | Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo. Group: Biochemicals. Alternative Names: Ro 32-0432, BIM XI. Grades: Highly Purified. CAS No. 145333-02-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O2 HCl. US Biological Life Sciences. | Worldwide |
| Bryostatin 1 | Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BRYOSTATIN 1;BRYO 1;2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en;BRYOSTATIN;bryostatin1,0;(26R)-Bryostatin 1;NSC-339555;(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl2,4-octadienoicacidester. Product Category: Inhibitors. Appearance: solid. CAS No. 83314-01-6. Molecular formula: C47H68O17. Mole weight: 905.03. Purity: ≥99.0%. Product ID: ACM83314016. Alfa Chemistry ISO 9001:2015 Certified. | |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Synonyms: BX 795; BX795. Grades: ≥98%. CAS No. 702675-74-9. Molecular formula: C23H26IN7O2S. Mole weight: 591.47. | |
| BX912 | BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM; >10 fold selectivity over PKA, PKC, C-Kit, EGFR etc. Synonyms: BX912; BX 912; BX-912. Grades: 0.98. CAS No. 702674-56-4. Molecular formula: C20H23BrN8O. Mole weight: 471.363. | |
| C-1 | C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 μM, respectively) and is widely used as a ROCK inhibitor. Synonyms: HA 100; HA100; HA-100; 5-Piperazin-1-ylsulfonylisoquinoline; 1-(5-Isoquinolinesulfonyl)piperazine. Grades: ≥99% by HPLC. CAS No. 84468-24-6. Molecular formula: C13H15N3O2S. Mole weight: 277.34. | |
| Calphostin C | Calphostin C is a highly selective PKC inhibitor ( IC 50 =0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UCN-1028C. CAS No. 121263-19-2. Pack Sizes: 100 μg. Product ID: HY-105416. | |
| Calphostin C (UCN 1028C, PKF115-584, Cal-C) | Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion. Source:Cladosporium cladosporioides sp. Group: Biochemicals. Grades: Highly Purified. CAS No. 121263-19-2. Pack Sizes: 100ug, 1mg. Molecular Formula: C44H38O14 , Molecular Weight: ~790.8. US Biological Life Sciences. | Worldwide |
| CaMKII-IN-1 | CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. Synonyms: CaMKII-IN-1; CaMKII; CaMKII IN-1; CaMKII IN 1; CaMKII-IN 1. Grades: >98%. CAS No. 1208123-85-6. Molecular formula: C29H30ClN5O2S. Mole weight: 548.1. | |
| CaMKII Inhibitor XII (Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII) | A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063uM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21uM for CaMKIV, MLCK, p38alpha, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CAY10621 | Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. The two known kinases, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2), have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. CAY10621 is an inhibitor of SPHK1 with IC50 of 3.3 μM. It is selective for SphK1 over Sph2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SphK1 activity by 70% in U937 cells at 5 μM. Synonyms: SKI 5C; SPHK1 Inhibitor 5C; CAY 10621; CAY-10621. Grades: ≥98%. CAS No. 120005-55-2. Molecular formula: C26H45NO4. Mole weight: 435.6. | |
| CEP-5214 | CEP-5214 is a potent, low-nanomolar pan inhibitor of human VEGF-R tyrosine kinases, displaying IC(50) values of 16, 8, and 4 nM for VEGF-R1/FLT-1, VEGF-R2/KDR, and VEGF-R3/FLT-4, respectively, with cellular activity equivalent to the isolated enzyme activity. Compound 21 exhibited good selectivity against numerous tyrosine and serine/threonine kinases including PKC, Tie2, TrkA, CDK1, p38, JNK, and IRK. Synonyms: CEP 5214; CEP5214; 3-(5,6,7,13-tetrahydro-9-((1-methylethoxy)methyl)-5-oxo-12h-indeno(2,1-a)pyrrolo(3,4-c)carbazol-12-yl)propanol; 12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-5-one. CAS No. 402857-39-0. Molecular formula: C28H28N2O3. Mole weight: 440.54. | |
| Cercosporamide | Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3. Cercosporamide effectively inhibits eIF4E phosphorylation as well as inibitiing inhibits Pkc1. Cercosporamide displays antiproliferative and proapoptotic activity in cancer cells in vitro. Group: Biochemicals. Alternative Names: (9aS) -8-Acetyl -9, 9a-di hydro-1, 3, 7-tri hydroxy-9a- methyl -9-oxo-4-dibenzofurancarboxamid e ; (S)-8-Acetyl -9, 9a-di hydro-1, 3, 7-tri hydroxy-9a- methyl -9-oxo-4-dibenzofurancarboxamid e ; (-)-Cercosporamide. Grades: Highly Purified. CAS No. 131436-22-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cercosporin | Phytotoxin. Potent and specific PKC inhibitor. Competes for the phorbol binding site. Anticancer compound. Cytotoxic. Antiproliferative. Antiparasitic. Antimicrobial. Group: Biochemicals. Alternative Names: NSC 153111. Grades: Highly Purified. CAS No. 35082-49-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C29H26O10. US Biological Life Sciences. | Worldwide |
| CGP 53353 | CGP 53353, also called DAPH 2, highly selectively inhibits procarcinogenic protein kinase C-βII (PKCβII) ,and it is also an inhibitor of prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM). It inhibits de novo Aβ42 assembly in vitro. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CGP53353; CGP 53353; CGP-53353. 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; DAPH 2; CGP-53353; 145915-60-2; DAPH-7; PKCbetaII/EGFR Inhibitor; CHEMBL7939; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; IN1137; 4,5-bis(4-Fluoroanilino)-phthalimide; CGP 53 353; CG53353; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; DAPH-2; MolMap_000016; C7866_SIGMA; SCHEMBL230492; GTPL5163; CTK8E9235; RONQPWQYDRPRGG-UHFFFAOYSA-N; HMS3229K07; HMS3269E05; ZINC600430; CGP53353; BDBM50040930; CGP 53353; DNC003638; MFCD00938569; AKOS015911570; CCG-206784; NCGC00159569-01; NCGC00159569-02; AK394840; HE005407; HE312152; ZB014534; DB-042814; FT-0643387; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis-(4-fluoro-phenylamino)-isoindole-1,3-dione; BRD-K32292990-001-01-0; I14-37922; 5,6-bis[(4-fluorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione; CGP 53353|5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione. CAS No. 145915-60-2. Molecular formula: C20H13F2N3O2. Mole weight: 365.34. | |
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