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| Product | Description | |
|---|---|---|
| Plinabulin | Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 value of 9.8~18 nM in tumor cells under the development of Nereus Pharmaceuticals. It can bind to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. In Sep 2016, BeyondSpring Pharmaceuticals planed a phase II/III trial for Neutropenia. Phase I clinical trials for Solid tumours and Phase III clinical trials for Non-small cell lung cancer are on-going. Uses: Non-small cell lung cancer; neutropenia;solid tumours. Synonyms: NPI 2358; NPI2358; NPI-2358; Plinabulin; UNII-986FY7F8XR; (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione. Grades: 98%. CAS No. 714272-27-2. Molecular formula: C19H20N4O2. Mole weight: 339.39. |  |
| Plinabulin | Plinabulin (NPI-2358) is a vascular disrupting agen ( VDA ) against tubulin-depolymerizing with an IC 50 of 9.8 nM against HT-29 cells [1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NPI-2358. CAS No. 714272-27-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14444. |  |
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