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| Product | Description | |
|---|---|---|
| Plitidepsin | Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K D =80?nM) [1]. Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC 90 of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Aplidine; PM90001. CAS No. 137219-37-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16050. |  |
| Plitidepsin | Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Group: Inhibitors. Alternative Names: aplidine; dehydrodemnin B. US brand name: Aplidin. CAS No. 137219-37-5. Molecular formula: C57H87N7O15. Mole weight: 1110.34. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-N-((R)-1-(((3S, 6R, 7S, 10R, 11S, 15S, 17S, 20S, 25aS)-10-((S)-sec-butyl)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2, 6, 17-trimethyl-1, 4, 8, 13, 16, 18, 21-heptaoxodocosahydro-15H-pyrrolo[2, 1-f][1, 15]dioxa[4, 7, 10, 20]tetraazacyclotricosin-7-yl)amino)-4-methyl-1-oxopentan-2-yl)-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide. Canonical SMILES: CC[C@@H] ([C@@H]1[C@@H] (O)CC (O[C@@H] (C (C)C)C ([C@H] (C)C (N[C@@H] (CC (C)C)C (N2CCC[C@H]2C (N (C)[C@@H] (CC3=CC=C (OC)C=C3)C (O[C@H] (C)[C@H] (NC ([C@H] (N (C ([C@@H]4CCCN4C (C (C)=O)=O)=O)C)CC (C)C)=O)C (N1)=O)=O)=O)=O)=O)=O)=O)C. Catalog: ACM137219375. |  |
| Plitidepsin | Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin shows potent anticancer activity against a large variety of cultured human cancer cells, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Synonyms: aplidin; aplidine; plitidepsin; dehydrodidemnin B. Grades: >98%. CAS No. 137219-37-5. Molecular formula: C57H87N7O15. Mole weight: 1110.34. |  |
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