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| Product | Description | |
|---|---|---|
| PLpro inhibitor | Cas No. 1093070-14-4. |  |
| PLpro inhibitor | PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC 50 of 2.6 μM [1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC 50 of 5.0 μM and an EC 50 of 21.0 μM [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093070-14-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17542. |  |
| 4'-O-Methylbavachalcone | 4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 20784-60-5. Molecular formula: C21H22O4. Mole weight: 338.4. Purity: 0.9985. Canonical SMILES: O=C(C1=CC(C/C=C(C)\C)=C(OC)C=C1O)/C=C/C2=CC=C(O)C=C2. Product ID: ACM20784605. Alfa Chemistry ISO 9001:2015 Certified. Categories: CHEBI:85123. |  |
| 6-Thioguanine | 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases ( PLpros ) and also potently inhibits USP2 activity, with IC 50 s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Thioguanine; 2-Amino-6-purinethiol. CAS No. 154-42-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-13765. | |
| 6-Thioguanine (Standard) | 6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases ( PLpros ) and also potently inhibits USP2 activity, with IC 50 s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. Uses: Scientific research. Group: Natural products. CAS No. 154-42-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13765R. | |
| DUB Inhibitor V, PR-619 | A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains. Group: Biochemicals. Alternative Names: PR619; UCH-L1 Inhibitor IV; UCH-L3 Inhibitor II; UCH-L5/UCH37 Inhibitor III; USP5 Inhibitor II; USP7 Inhibitor I; USP9X Inhibitor II; USP14 Inhibitor IV; USP14 Inhibitor IV; USP47 Inhibitor I; 2,6-Diaminopyridine-3,5-bis(thiocyanate); 3,5-Dithiocyanatopyridine-2,6-diamine. Grades: Highly Purified. CAS No. 21645-32-1. Pack Sizes: 25mg. Molecular Formula: C?H?N?S?, Molecular Weight: 223.3. US Biological Life Sciences. |  Worldwide |
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