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| Product | Description | |
|---|---|---|
| PLX5622 | PLX5622 Inhibitor. Uses: Scientific use. Product Category: T7100. CAS No. 1303420-67-8. |  |
| PLX5622 | PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ?M; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1303420-67-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114153. |  |
| PLX5622 fumarate | PLX5562 is a highly selective brain-penetrant CSF1R inhibitor. In the 5xFAD mouse model of AD, plaques fail to form in the parenchymal space following microglial depletion, except in areas containing surviving microglia. Microglia appear to contribute to multiple facets of AD etiology - microglia appear crucial to the initial appearance and structure of plaques, and following plaque formation, promote a chronic inflammatory state modulating neuronal gene expression changes in response to Aβ/AD pathology. PLX5622 demonstrated desirable PK properties in mice, rats, dogs, and monkeys with a brain penetrance of ~20%. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PLX5622; PLX-5622; PLX 5622; PLX5622 fumarate. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2749102-07-4. Molecular formula: C46H42F4N10O6. Mole weight: 906.9. Purity: >98%. IUPACName: 6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine hemifumarate. Canonical SMILES: CC1=CN=C(NC=C2CC3=C(F)N=C(NCC4=CC(F)=CN=C4OC)C=C3)C2=C1.O=C(O)/C=C/C(O)=O.CC5=CN=C(NC=C6CC7=C(F)N=C(NCC8=CC(F)=CN=C8OC)C=C7)C6=C5. Product ID: ACM2749102074. Alfa Chemistry ISO 9001:2015 Certified. Categories: 6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine fumarate. |  |
| PLX5622 hemifumarate | PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ?M; Ki=5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 hemifumarate demonstrates desirable PK properties in varies animals[1][2]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114153A. | |
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