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| Product | Description | |
|---|---|---|
| PMX 53 | PMX 53. Group: Biochemicals. Grades: Purified. CAS No. 219639-75-5. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| PMX 53 | PMX 53 is a dual C5aR(CD88) antagonist and Mas-related gene 2 (MrgX2) agonist. It stimulates MrgX2-mediated mast cell degranulation, and also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. Synonyms: L-Arginine, N-acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-, (6?2)-lactam; 3D53; C 5aRA; PMX53; PMX-53; Ac-Phe-Orn(1)-Pro-D-Cha-Trp-Arg-(1); Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg); Ac-Phe-[Orn-Pro-cha-Trp-Arg]. Grades: >98%. CAS No. 219639-75-5. Molecular formula: C47H65N11O7. Mole weight: 896.09. |  |
| PMX 53 acetate | PMX 53 is a potent and orally active C5aR(CD88) antagonist and Mas-related gene 2 (MrgX2) agonist. It stimulates MrgX2-mediated mast cell degranulation, inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis, inhibits lung metastasis in a mouse breast cancer model, and reduces atherosclerotic lesions in a mouse model of atherosclerosis. Synonyms: L-Arginine, N-acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-, (6?2)-lactam, monoacetate; Ac-Phe-Orn(1)-Pro-D-Cha-Trp-Arg-(1).CH3CO2H; C 5aRA acetate salt. Grades: ≥95%. CAS No. 852629-88-0. Molecular formula: C47H65N11O7.C2H4O2. Mole weight: 956.14. | |
| PMX 53c | PMX 53c is negative control for PMX 53. PMX-53 functions as a potent CD88 antagonist and a low-affinity agonist for MrgX2. Furthermore, Trp and Arg residues are required for the ability of PMX53 to act as both a CD88 antagonist and a MrgX2 agonist. Synonyms: PMX 53c; PMX-53c; PMX53c; N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide. CAS No. 827600-15-7. Molecular formula: C39H60N10O7. Mole weight: 780.96. | |
| PMX 53 TFA | PMX 53 is a dual C5aR (CD88) antagonist and Mas-related gene 2 (MrgX2) agonist. It stimulates MrgX2-mediated mast cell degranulation, and also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. Synonyms: L-Arginine, N-acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-, (6?2)-lactam, mono(trifluoroacetate); PMX53 TFA; PMX-53 TFA; PMX 53 Trifluoroacetate; PMX53 Trifluoroacetate; PMX-53 Trifluoroacetate. Grades: ≥95%. CAS No. 852629-87-9. Molecular formula: C49H66F3N11O9. Mole weight: 1010.11. | |
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