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| Product | Description | |
|---|---|---|
| PNU 37883 hydrochloride | PNU 37883 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 57568-80-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| PNU 37883 hydrochloride | PNU 37883 is a potent, euglycemic vascular K-ATP blocker that also exerts a K+-sparing diuresis at higher doses. It selectively inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. PNU 37883 is useful biological tool in distinguishing between Kir6.1 and Kir6.2 chimeric protein functions as well as the different sulfonylurea-sensitive K+ channel subtypes. Uses: Diuretics. Synonyms: U 37883A; U37883A; U-37883A; PNU 37883; PNU37883; PNU-37883; N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 57568-80-6. Molecular formula: C21H35N3O.HCl. Mole weight: 381.98. |  |
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