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| Product | Description | |
|---|---|---|
| PNU-120596 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PNU-120596 | PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. Synonyms: PNU-120596; PNU 120596; PNU120596; NSC 216666; NSC-216666; NSC216666. Grades: >98%. CAS No. 501925-31-1. Molecular formula: C13H14ClN3O4. Mole weight: 311.72. |  |
| PNU-120596 | PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC 50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 216666. CAS No. 501925-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12152. |  |
| PNU-120596 (a7 nAChR Agonist, 1-(5-chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea, α7 Neuronal Nicotinic Acetylcholine Receptor Agonist) | A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the a7 subtype of neural nicotinic acetylcholine receptors (EC50 = 216nM), with no significant effect on a4B2, a3B4 and a9a10 receptors. Specifically increase a-7 nAChR-mediated channel currents and channel mean open time in cultured neurons (~1mM). However, it does neither affect ion selectivity nor unitary conductance. Shown to cross the blood-brain barrier. Causes conformational changes in the ligand binding domain of a7 nicotinic receptors that partially overlap with those caused by acetylcholine. Causes changes in cysteine accessibility at the inner beta sheet, transition zone, and agonist binding site. Also reported to potentiate agonist-evoked GABAergic postsynaptic inward currents in somatodendritic membrane of hippocampal interneurons. Group: Biochemicals. Grades: Highly Purified. CAS No. 501925-31-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PNU-120596 - CAS 501925-31-1 | A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the ?7 subtype of neural nicotinic acetylcholine receptors. Group: Fluorescence/luminescence spectroscopy. | |
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