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| Product | Description | |
|---|---|---|
| Poloxin | Poloxin is the first small-molecule inhibitor specifically targeting the function of the Plk1 PBD. Poloxin induces centrosome fragmentation and abnormal spindle and chromosome misalignment, which activate the spindle assembly checkpoint and prolong mitosis. Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes. Moreover, Poloxin strongly inhibits proliferation of a panel of cancer cells by inducing mitotic arrest, followed by a surge of apoptosis. More important, we report, for the first time to our knowledge, that the PBD inhibitor, Poloxin, significantly suppresses tumor growth of cancer cell lines in xenograft mouse models by lowering the proliferation rate and triggering apoptosis in treated tumor tissues. Targeting the PBD by Poloxin is a powerful approach for selectively inhibiting Plk1 function in vitro and in vivo. Synonyms: Poloxin. Grades: 0.98. CAS No. 321688-88-4. Molecular formula: C18H19NO3. Mole weight: 297.354. |  |
| Polo-like Kinase Inhibitor V, Poloxin (2-isopropyl-5-methyl-4- (2-methylbenzoyloxyimino) cyclohexa-2, 5-dienone) | A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50)=4.8uM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25uM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40mg/kg. Group: Biochemicals. Grades: Highly Purified. CAS No. 321688-88-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 | The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
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