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Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin. Uses: Scientific research. Group: Natural products. CAS No. 487-90-1. Pack Sizes: 1 mg. Product ID: HY-W013495.
Porphobilinogen
Porphobilinogen. Group: Biochemicals. Alternative Names: 5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid. Grades: Highly Purified. CAS No. 487-90-1. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C10H14N2O4. US Biological Life Sciences.
?99 atom % 13C, ?95% (CP). Group: Fluorescence/luminescence spectroscopy.
porphobilinogen synthase
The enzyme catalyses the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430. The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis. The enzymes from most organisms utilize metal ions (Zn2+, Mg2+, K+, and Na+) as cofactors that reside at multiple sites, including the active site and allosteric sites. Enzymes from archaea, yeast, and metazoa (including human) contain Zn2+ at the active site. In humans, the enzyme is a primary target for ...; 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing); hemB (gene name). Enzyme Commission Number: EC 4.2.1.24. CAS No. 9036-37-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5016; porphobilinogen synthase; EC 4.2.1.24; 9036-37-7; aminolevulinate dehydratase; Δ-aminolevulinate dehydratase; Δ-aminolevulinic acid dehydrase; Δ-aminolevulinic acid dehydratase; aminolevulinic dehydratase; Δ-aminolevulinic dehydratase; 5-levulinic acid dehydratase; 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing); hemB (gene name). Cat No: EXWM-5016.
Acetoxyacetic acid
Acetoxyacetic acid (CAS# 13831-30-6) is a versatile organic building block, used in the synthesis of pharmaceutical compounds, including inhibitors and therapeutic agents. It can be used for the synthesis of analogs of 5-Aminolevulinic Acid, which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis. Synonyms: 2-acetyloxyacetic acid. CAS No. 13831-30-6. Molecular formula: C4H6O4. Mole weight: 118.09.
hydroxymethylbilane synthase
The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC 4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I. Group: Enzymes. Synonyms: HMB-synthase; porphobilinogen deaminase; pre-uroporphyrinogen synthase; uroporphyrinogen I synthase; uroporphyrinogen I synthetase; uroporphyrinogen synthase; uroporphyrinogen synthetase; porphobilinogen ammonia-lyase (polymerizing); (4-[2-car. Enzyme Commission Number: EC 2.5.1.61. CAS No. 9074-91-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2799; hydroxymethylbilane synthase; EC 2.5.1.61; 9074-91-3; HMB-synthase; porphobilinogen deaminase; pre-uroporphyrinogen synthase; uroporphyrinogen I synthase; uroporphyrinogen I synthetase; uroporphyrinogen synthase; uroporphyrinogen synthetase; porphobilinogen ammonia-lyase (polymerizing); (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing). Cat No: EXWM-2799.
uroporphyrinogen-III synthase
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen. Group: Enzymes. Synonyms: porphobilinogenase; uroporphyrinogen isomerase; uroporphyrinogen III cosynthase; URO-synthase; hydroxymethylbilane hydro-lyase (cyclizing). Enzyme Commission Number: EC 4.2.1.75. CAS No. 37340-55-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5059; uroporphyrinogen-III synthase; EC 4.2.1.75; 37340-55-9; porphobilinogenase; uroporphyrinogen isomerase; uroporphyrinogen III cosynthase; URO-synthase; hydroxymethylbilane hydro-lyase (cyclizing). Cat No: EXWM-5059.
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