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| Product | Description | |
|---|---|---|
| Poziotinib | Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: HM781-36B; NOV120101; NOV-120101; NOV 120101; Poziotinib. CAS No. 1092364-38-9. Molecular formula: C23H21Cl2FN4O3. Mole weight: 491.344. |  |
| Poziotinib | Poziotinib (HM781-36B) is an orally active, irreversible pan- HER inhibitor, which effectively inhibits EGFR wt , HER-2 and HER-4 with IC 50 s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFR T790M and EGFR L858R/T790M , with IC 50 s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HM781-36B; NOV120101. CAS No. 1092364-38-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15730. |  |
| Poziotinib Hydrochloride | Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: Poziotinib HCl; NOV120101 hydrochloride; HM 781-36B hydrochloride. CAS No. 1429757-68-5. Molecular formula: C23H22Cl3FN4O3. Mole weight: 527.80. | |
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