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| Product | Description | |
|---|---|---|
| PR-104 | PR-104 is a non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous administration, PR-104 is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing normoxic tissues. Synonyms: PR 104; PR104; 2- ( (2-Bromoethyl) (2, 4-dinitro-6- ( (2- (phosphonooxy) ethyl) carbamoyl) phenyl) amino) ethyl methanesulfonate; Benzamide, 2-[(2-bromoethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitro-N-[2-(phosphonooxy)ethyl]-. Grades: ≥97%. CAS No. 851627-62-8. Molecular formula: C14H20BrN4O12PS. Mole weight: 579.27. |  |
| PR-104 | PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851627-62-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-16405. |  |
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