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| Product | Description | |
|---|---|---|
| Pralatrexate | Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment [1] [2] [3] [4]. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 146464-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10446. |  |
| Pralatrexate | Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Uses: Aminopterin/ analogs & derivatives; folic acid antagonists. Synonyms: Pralatrexate;Folotyn; 10-Propargyl-10-deazaaminopterin; HSDB 7786; pralatrexato; pralatrexatum; PDX; CHEBI:71223; NSC-754230; UNII-A8Q8I19Q20; Pralatrexate(Folotyn); DTXSID3048578; A8Q8I19Q20; (2S)-2-(4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzamido)pentanedioic acid; N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-; DTXCID3028504; 146464-95-1 (racemic); NSC754230; NSC 754230; (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid; NCGC00242596-01; (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid. Grades: >98%. CAS No. 146464-95-1. Molecular formula: C23H23N7O5. Mole weight: 477.47. |  |
| R-Pralatrexate | The R isometric form of Pralatrexate which is a folate analog used to treat relapsed or refractory peripheral T-cell lymphoma. Synonyms: Pralatrexate, (R)-; (R)-pralatrexate; 1320211-70-8; UNII-9CY33O2XLX; 9CY33O2XLX; L-Glutamic acid, N-(4-((1R)-1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-; 1320211-70-8 (R-isomer); (4-((R)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamic acid; SCHEMBL1889869; DTXSID001031315; AKOS040747299; PD132342; HY-117791; CS-0068078; Q27272363; (2S)-2-[[4-[(2R)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid. Grades: > 95%. CAS No. 1320211-70-8. Molecular formula: C23H23N7O5. Mole weight: 477.48. | |
| S-Pralatrexate | The S isometric form of Pralatrexate which is a 10-deazaaminopterin analog of methotrexate, and is an inhibitor of DHFR. Synonyms: Pralatrexate, (S)-; 1320211-69-5; UNII-0892G4T376; 0892G4T376; L-Glutamic acid, N-(4-((1S)-1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-; (4-((S)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamic acid; (S)-pralatrexate; SCHEMBL1890561; DTXSID601031325; AKOS040747300; Q27236394; (2S)-2-[[4-[(2S)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid. Grades: > 95%. CAS No. 1320211-69-5. Molecular formula: C23H23N7O5. Mole weight: 477.48. | |
| Methotrexate Impurity 24 | Methotrexate Impurity 24. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Pralatrexate Impurity 3. CAS No. 716-74-5. Molecular Formula: C7H6N6O2. Mole Weight: 206.17. Catalog: APB716745. |  |
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