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| Product | Description | |
|---|---|---|
| PRIMA-1 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| PRIMA-1 | PRIMA-1. Group: Biochemicals. Grades: Purified. CAS No. 5608-24-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| PRIMA-1 | PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high μM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. Synonyms: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one. Grades: ≥99% by HPLC. CAS No. 5608-24-2. Molecular formula: C9H15NO3. Mole weight: 185.22. |  |
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