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| Product | Description | |
|---|---|---|
| Pritelivir | Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex , exhibits antiviral activity in vitro and in animal models of herpes simplex virus ( HSV ) infection. Pritelivir is active against herpes simplex virus types 1 and 2 ( HSV-1 and HSV-2 ) with the IC 50 of 0.02 μM against HSV1-2 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AIC316; BAY 57-1293. CAS No. 348086-71-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15303. |  |
| Pritelivir mesylate | Pritelivir, also known as AIC-316 and BAY 57-1293, is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. The compound shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes, in a murine zosteriform spread model of cutaneous disease, and in a murine ocular herpes model. It is active in parenteral, oral, and topical formulations. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pritelivir mesylate, BAY57-1293; BAY 57-1293; BAY-57-1293; BAY571293; BAY 571293; BAY-571293; AIC-316; AIC 316; AIC316. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1428333-96-3. Molecular formula: C19H22N4O6S3. Mole weight: 498.59. Purity: >98%. IUPACName: N-methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide mesylate. Canonical SMILES: O=C(N(C)C1=NC(C)=C(S(=O)(N)=O)S1)CC2=CC=C(C3=NC=CC=C3)C=C2.OS(=O)(C)=O. Product ID: ACM1428333963. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Pritelivir mesylate | Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex , exhibits antiviral activity in vitro and in animal models of herpes simplex virus ( HSV ) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 ( HSV-1 and HSV-2 ) with the IC 50 of 0.02 μM against HSV1-2 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AIC316 mesylate; BAY 57-1293 mesylate. CAS No. 1428333-96-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15303A. | |
| BAY-57-1293 | BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. Uses: For research used only. Synonyms: Pritelivir; BAY-57-1293; BAY 57-1293; BAY-57 1293; BAY 57 1293; BAY571293; AIC316; AIC 316; AIC-316. Grades: 98%. CAS No. 348086-71-5. Molecular formula: C18H18N4O3S2. Mole weight: 402.49. |  |
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