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| Product | Description | |
|---|---|---|
| PRL-3 Inhibitor | PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits phosphatase of regenerating liver 3 (PRL-3). It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. Synonyms: BR-1; P0108; Phosphatase of Regenerating Liver 3 Inhibitor; PTP4A3 Inhibitor; 1-(2-Bromobenzyloxy)-4-bromo-2-benzylidene rhodanine. Grades: ≥98%. CAS No. 893449-38-2. Molecular formula: C17H11Br2NO2S2. Mole weight: 485.2. |  |
| PRL-3 Inhibitor (BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor) | Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50=900nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines. Group: Biochemicals. Alternative Names: 5-[[5-bromo-2-[(2-bromophenyl) methoxy] phenyl] methylene] -2- thioxo-4-thiazolidinone. Grades: Highly Purified. CAS No. 893449-38-2. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C17H11Br2NO2S2. US Biological Life Sciences. |  Worldwide |
| PRL-3 Inhibitor I | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
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