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| Product | Description | |
|---|---|---|
| protein phosphatase methylesterase-1 | A key regulator of protein phosphatase 2A. The methyl ester is formed by EC 2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus. Group: Enzymes. Synonyms: PME-1; PPME1. Enzyme Commission Number: EC 3.1.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3518; protein phosphatase methylesterase-1; EC 3.1.1.89; PME-1; PPME1. Cat No: EXWM-3518. |  |
| ABL 127 | ABL 127 is a covalent aza-β-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 4.2 nM). Grade: ≥98%. CAS No. 1073529-41-5. Molecular formula: C17H20N2O5. Mole weight: 332.4. |  |
| [phosphatase 2A protein]-leucine-carboxy methyltransferase | Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes. Group: Enzymes. Synonyms: leucine carboxy methyltransferase-1; LCMT1. Enzyme Commission Number: EC 2.1.1.233. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1836; [phosphatase 2A protein]-leucine-carboxy methyltransferase; EC 2.1.1.233; leucine carboxy methyltransferase-1; LCMT1. Cat No: EXWM-1836. | |
| PME-1 Inhibitor, AMZ-30 | A cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50=600nM and 2.5uM in human cell lysates and in HEK 293T cells, (respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20uM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?S?, Molecular Weight: 462.6. US Biological Life Sciences. |  Worldwide |
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