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| Product | Description | |
|---|---|---|
| PRT4165 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PRT4165 | PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. Synonyms: PRT4165; PRT-4165; PRT 4165. Grades: 98%. CAS No. 31083-55-3. Molecular formula: C15H9NO2. Mole weight: 235.24. |  |
| Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) | A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2alpha ubiquitination at 25 and 50uM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50uM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33uM, respectively) by preventing Top2alpha degradation following VM26 treatment (100% inhibition at 50uM in HeLa cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 31083-55-3. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
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