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| Product | Description | |
|---|---|---|
| PTC-209 hydrobromide | Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth. It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential. Synonyms: PTC-209; PTC 209; PTC209 Hydrobromide; N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine hydrobromide. Grades: >98%. CAS No. 1217022-63-3. Molecular formula: C17H14Br3N5OS. Mole weight: 576.1. |  |
| PTC-209 hydrobromide | PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC 50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1217022-63-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15888A. |  |
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