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| Product | Description | |
|---|---|---|
| pTp | pTp is a competitive inhibitor of staphylococcal nuclease. Synonyms: Thymidine- 3', 5'- O- bisphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 2863-4-9. Molecular formula: C10H16N2O11P2. Mole weight: 402.2. |  |
| PTP1B (1-321)/PTPN1 Active from mouse | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| PTP1B (1-321)/PTPN1 Active from rat | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PTP1B (1-321)/PTPN1 Active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PTP1B full length Active human | recombinant, expressed in E. coli, ?50% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PTP1B-IN-1 | PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor. Synonyms: PTP1B-IN-1; PTP1B IN 1; PTP1BIN1; PTP1B inhibitor 1; PTP1B-inhibitor-1. Grades: >98%. CAS No. 612530-44-6. Molecular formula: C8H8N2O3S. Mole weight: 212.23. | |
| Ptp1B-In-2 | Ptp1B-In-2 is a selective protein tyrosine phosphatase-1B (PTP1B) inhibitor. Synonyms: Ptp1B In 2; MDK3465; MDK-3465; MDK 3465; methyl 5-(N-(4-(N-(2-methoxy-2-oxoethyl)methylsulfonamido)benzyl)-1-phenylmethylsulfonamido)-2-((4-methylbenzyl)oxy)benzoate. CAS No. 1919853-46-5. Molecular formula: C34H36N2O9S2. Mole weight: 680.79. | |
| PTP1B-IN-3 | PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC 50 s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 809272-64-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-15133. |  |
| PTP1B-IN-3 diammonium | PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC 50 s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2702673-78-5. Pack Sizes: 1 mg. Product ID: HY-15133A. | |
| PTP1B Inhibitor | PTP1B inhibitor is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), which is involved in cell signaling relevant to diabetes, obesity, and cancer. Synonyms: Protein Tyrosine Phosphatase 1B Inhibitor; FRJ; 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide. Grades: ≥98%. CAS No. 765317-72-4. Molecular formula: C26H19Br2N3O7S3. Mole weight: 741.5. | |
| PtPC | PtPC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Phthalocyanine platinum. Product Category: Organic Light Emitting Diode (OLED). CAS No. 14075-08-2. Molecular formula: C32H16N8Pt. Mole weight: 707.6 g/mol. Product ID: ACM14075082. Alfa Chemistry ISO 9001:2015 Certified. Categories: PTPRK. |  |
| PTP-D2/PTPN14 Active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PtPd/graphene nanocomposite | 10 mg/mL, dispersion in acetone. Group: Nanomaterials for 3d printing. | |
| PtPd/graphene nanocomposite | PtPd/graphene nanocomposite. Uses: Efficient electrocatalyst material for fuel cells including methanol oxidation, proton exchange membrane. Group: 3d printing materials carbon nano materials. |  |
| PtPd/reduced graphene oxide nanocomposite | 10 mg/mL, dispersion in acetone. Group: Nanomaterials for 3d printing. | |
| PtPd/reduced graphene oxide nanocomposite | PtPd/reduced graphene oxide nanocomposite. Uses: Efficient electrocatalyst material for fuel cells including methanol oxidation, proton exchange membrane. Group: 3d printing materials carbon nano materials. | |
| PTPIA2 Active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PTP Inhibitor III | PTP Inhibitor III is a cell-permeable inhibitor of protein tyrosine phosphatase (PTP), a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. It binds to the catalytic domain of SHP-1 with Ki value of 184 μM. Synonyms: α-Bromo-4-(carboxymethoxy)acetophenone; Protein Tyrosine Phosphatase Inhibitor III; 2-[4-(2-Bromoacetyl)phenoxy]acetic acid. Grades: ≥95%. CAS No. 29936-81-0. Molecular formula: C10H9BrO4. Mole weight: 273.1. | |
| PTP Inhibitor IV | PTP inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-μ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 μM, respectively). Synonyms: Protein Tyrosine Phosphatase Inhibitor IV; Bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene; 1, 1, 1-trifluoro-N-[4-[2-[4-[2-[4- (trifluoromethylsulfonylamino) phenyl]propan-2-yl]phenyl]propan-2-yl]phenyl]methanesulfonamide. Grades: ≥98%. CAS No. 329317-98-8. Molecular formula: C26H26F6N2O4S2. Mole weight: 608.6. | |
| PTPmu Active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PTPN11 (246-593), active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPN12 (1-355), active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPN13 (2169-2485), active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPN1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPN2, active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPN6, active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPN7, active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPRA (174-802), active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPRC (592-end), active, GST tagged from mouse | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPRE, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPRF (1275-1897), active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PTPRM (764-1452), GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-PTPN11 (pTyr542) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-PTPN6 (pTyr536) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-PTPRA (pTyr798) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-PTP4A3 antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-PTPN12 antibody produced in rabbit | affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-PTPRA antibody produced in rabbit | ~1.0 mg/mL. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-PTPRC antibody produced in chicken | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-PTPRF antibody produced in rabbit | IgG fraction of antiserum. Group: Fluorescence/luminescence spectroscopy. | |
| Cdc25 Inhibitor IV, NSC 95397 (2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione, PTP Inhibitor XXIX) | A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki=32nM, 96nM, and 40nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50=1.8uM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. Group: Biochemicals. Grades: Highly Purified. CAS No. 93718-83-3. Pack Sizes: 10mg. Molecular Formula: C??H??O?S?, Molecular Weight: 310.4. US Biological Life Sciences. |  Worldwide |
| Monoclonal Anti-PTP4A2 antibody produced in mouse | clone 3C2, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-PTPA/ PPP2R4 antibody produced in mouse | ~1.0 mg/mL, clone 5G3, purified immunoglobulin. Group: Fluorescence/luminescence spectroscopy. | |
| PRL-3 Inhibitor (BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor) | Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50=900nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines. Group: Biochemicals. Alternative Names: 5-[[5-bromo-2-[(2-bromophenyl) methoxy] phenyl] methylene] -2- thioxo-4-thiazolidinone. Grades: Highly Purified. CAS No. 893449-38-2. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C17H11Br2NO2S2. US Biological Life Sciences. | Worldwide |
| TC-PTP Active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| 1,1-Dioxide-5-(4-bromophenyl)-1,2,5-thiadiazolidin-3-one | 1,1-Dioxide-5-(4-bromophenyl)-1,2,5-thiadiazolidin-3-one isused in the preparation of phenyl thiadiazolidinones as inhibitors of protein tyrosine phosphatase 1B (PTP1B) for treatment of diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 692765-79-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C8H7BrN2O3S, Molecular Weight: 291.12. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-(1-naphthyl)thiazole | 2-Amino-4-(1-naphthyl)thiazole is a reagent used in the synthesis of 2-substituted ethenesulfonic acid ester derivatives as PTP1B inhibitors. Also used as a reagent in the preparation of pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors for the treatment of inflammation and various cancers. Group: Biochemicals. Grades: Highly Purified. CAS No. 56503-96-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10N2S, Molecular Weight: 226.3. US Biological Life Sciences. | Worldwide |
| 2-Bromo-4,6-diphenyl-1,3,5-triazine | 2-Bromo-4,6-diphenyl-1,3,5-triazine. Group: Small molecule semiconductor building blockssemiconductor blocks. CAS No. 80984-79-8. Product ID: 2-bromo-4,6-diphenyl-1,3,5-triazine. Molecular formula: 312.17. Mole weight: C15H10BrN3. C1=CC=C (C=C1)C2=NC (=NC (=N2)Br)C3=CC=CC=C3. InChI=1S/C15H10BrN3/c16-15-18-13 (11-7-3-1-4-8-11)17-14 (19-15)12-9-5-2-6-10-12/h1-10H. PTPGZCQGDXUUAH-UHFFFAOYSA-N. >98.0%(GC). | |
| 2-Bromo-4'-hydroxyacetophenone | 2-Bromo-4'-hydroxyacetophenone a PTP1B inhibitor, with a K i of 42 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2491-38-5. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W002314. | |
| 2-Bromo-4'-hydroxyacetophenone | A covalent inhibitor of protein tyrosine phosphatases (PTPs). Group: Biochemicals. Alternative Names: 2-Bromo-1- (4-hydroxyphenyl) ethanone; 1-(4-Hydroxyphenyl)-2-bromoethanone; p-Hydroxyphenacyl Bromide; α-Bromo-4'-hydroxyacetophenone; Busan 1130; Busan 90; Butrol 1130. Grades: Highly Purified. CAS No. 2491-38-5. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 2-Bromo-4'-hydroxyacetophenone | PTP Inhibitor I is a cell-permeable inhibitor of protein tyrosine phosphatase (PTP), a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Synonyms: 2-bromo-1-(4-hydroxyphenyl)ethanone; 2-bromo-1-(4-hydroxyphenyl)ethanone. Grades: > 98 %. CAS No. 2491-38-5. Molecular formula: C8H7BrO2. Mole weight: 215.04. | |
| 2-Bromo-4'-methoxyacetophenone | 2-Bromo-4'-methoxyacetophenone is a α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. Group: Biochemicals. Alternative Names: 2-Bromo-1- (4-methoxyphenyl) ethanone; 2-(4-Methoxyphenyl)-2-oxoethyl bromide; 2-Bromo-1-(4-methoxyphenyl)-1-ethanone; 2-Bromo-1-[4- (methyloxy) phenyl]ethanone; 2-Bromo-p-methoxyacetophenone; 4-Methoxy-2'-bromoacetophenone; 4-Methoxyphenacyl Bromide; 4'-Methoxyphenacyl Bromide; Bromomethyl 4-Methoxyphenyl Ketone; Bromomethyl p-Anisyl Ketone; Bromomethyl p-Methoxyphenyl Ketone; NSC 129010; p-Methoxyphenacyl Bromide; α-Bromo-4'-methoxyacetophenone; α-Bromo-p-methoxyacetophenone; ω-Bromo-4'-methoxyacetophenone; ω-Bromo-p-methoxyacetophenone. Grades: Highly Purified. CAS No. 2632-13-5. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2-Chloro-2',4'-difluoroacetophenone | A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. Group: Biochemicals. Alternative Names: 2-Chloro-1- (2, 4-difluorophenyl) ethanone; Chloromethyl 2,4-Difluorophenyl Ketone; α-Chloro-2,4-difluoroacetophenone. Grades: Highly Purified. CAS No. 51336-94-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 2-Chloro-4-nitrophenyl phosphate | 2-Chloro-4-nitrophenyl phosphate, an indispensable compound in the field of biomedicine, possesses extraordinary capabilities in suppressing protein tyrosine phosphatases (PTPs). This fundamental trait renders it a promising avenue for therapeutic intervention against an array of ailments, encompassing malignancies and autoimmune disorders, by selectively targeting PTPs implicated in intricate signal transduction cascades. Synonyms: 2-Chloro-4-nitrophenyl dihydrogen phosphate; 14957-98-3; (2-chloro-4-nitrophenyl) dihydrogen phosphate; AGN-PC-0N3TPY; SCHEMBL1134003; DTXSID40439315; 2-Chloro-4-nitrophenyldihydrogenphosphate; (2-chloro-4-nitrophenoxy)phosphonic acid; A919724. CAS No. 14957-98-3. Molecular formula: C6H5ClNO6P. Mole weight: 253.53. | |
| 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide | 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide is an inhibitor of Protein tyrosine phosphatase 1B (PTP1B). Group: Biochemicals. Grades: Highly Purified. CAS No. 765317-72-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C26H19Br2N3O7S3, Molecular Weight: 741.45. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4-fluorobenzoic Acid | 3-Bromo-4-fluorobenzoic Acid is a building block used in the synthesis of a highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1007-16-5. Pack Sizes: 5g, 25g. Molecular Formula: C7H4BrFO2, Molecular Weight: 219.01. US Biological Life Sciences. | Worldwide |
| Acid phosphatase 1 from Human, recombinant | Acid phosphatase 1, also known as ACP1, belongs to the phosphotyrosine protein family. It functions as an acid phosphatase and a protein tyrosine phosphatase (PTPase) and is present in all human tissues, including adipocytes. This enzyme hydrolyzes protein tyrosine phosphate to protein tyrosine and orthophosphate, and also orthophosphoric monoesters to alcohol and orthophosphate. Group: Enzymes. Synonyms: Acid phosphatase 1; soluble isoform b; ACP1; HAAP; LMW-PTP; Red cell acid phosphatase 1; Adipocyte acid phosphatase. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: > 95% by SDS-PAGE. Apase. Mole weight: 20.1 kDa (178 aa, 1-158 aa + NT His-Tag). Activity: > 60,000 unit/mg of protein. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. Acid phosphatase 1; soluble isoform b; ACP1; HAAP; LMW-PTP; Red cell acid phosphatase 1; Adipocyte acid phosphatase; Acid Phosphatase. Cat No: NATE-1672. |  |
| Adenosine-5'-(4-fluorosulfonylphenylphosphate) | Adenosine-5'-(4-fluorosulfonylphenylphosphate) is a crucial compound in the biomedical industry. It is extensively utilized for studying the enzymatic activity of protein tyrosine phosphatases (PTPs). Additionally, this product serves as a valuable tool to investigate diseases like cancer, autoimmune disorders, and diabetes where PTP dysregulation plays a role. Its availability ensures accurate analysis and facilitates advancements in biomedicine research. Synonyms: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (4-fluorosulfonylphenyl) hydrogen phosphate;5'-Adenylic acid, mono(4-(fluorosulfonyl)phenyl) ester; 9- (5-O-{[4- (Fluorosulfonyl)phenoxy] (hydroxy)phosphoryl}pentofuranosyl)-9H-purin-6-amine. CAS No. 60397-89-9. Molecular formula: C16H17FN5O9PS. Mole weight: 505.37. | |
| Alexidine dihydrochloride | Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1 , in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1715-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108547. | |
| Alexidine dihydrochloride | Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus. Synonyms: 2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2); 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride; Biguanide, 1,1'-hexamethylenebis[5-(2-ethylhexyl)-, dihydrochloride; 1,6-Bis(2-ethylhexylbiguanido)hexane dihydrochloride; Alexidine hydrochloride; Hexamethylenebis(2-ethylhexyl)biguanide dihydrochloride. Grades: >98%. CAS No. 1715-30-6. Molecular formula: C26H58N10Cl2. Mole weight: 581.71. | |
| BCI hydrochloride | BCI hydrochloride is an allosteric inhibitor of Dusp6, acting within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM). It prevents pERK2 dephosphorylation induced by Dusp6 in vitro. It is selective for Dusp6 and Dusp1 over Dusp3/VHR, Cdc25B, and PTP1B, for which it has no activity. Synonyms: 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one hydrochloride. Grades: ≥95%. CAS No. 95130-23-7. Molecular formula: C22H23NO·HCl. Mole weight: 353.9. | |
| bpV(HOpic) | bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumor suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTP β and 25.3 μM for PTP-1 β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury. Group: Biochemicals. Alternative Names: Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V); Bisperoxovanadium (HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V). Grades: Highly Purified. CAS No. 722494-26-0. Pack Sizes: 5mg, 25mg. Molecular Formula: K2[VO(O2)2C6H4NO3], Molecular Weight: 347.24. US Biological Life Sciences. | Worldwide |
| bpV(HOpic) potassium salt | BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 4.9 μM and PTP-1βB with IC50 of 25.3 μM. It is reported to function as an insulin mimetic and activate the insulin receptor kinase (IRK). BpV(HOpic) has been shown to activate the insulin receptor kinase of hepatoma cells and enhance PI3K/Akt signaling, which could prevent ischemia-reperfusion (I/R) injury to the myocardium. Synonyms: Bisperoxovanadium(HOpic). Grades: ≥95%. CAS No. 722494-26-0. Molecular formula: C6H4NO8V·2K. Mole weight: 347.2. | |
| bpV(phen) (Potassium bisperoxo (1, 10-phenanthroline) oxovanadate (V)) | A bisperoxovanadium compound that acts as a potent protein phosphotyrosine phosphatase (PTP) inhibitor as well as an insulin receptor kinase (IRK) activator. Also an excellent insulin mimetic in vitro and in vivo and a potent PTEN inhibitor (IC50 = 38nM). Group: Biochemicals. Alternative Names: Potassium bisperoxo (1, 10-phenanthroline) oxovanadate (V). Grades: Highly Purified. CAS No. 42494-73-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| bpV(phen) potassium hydrate | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grades: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
| bpV(pic) (Dipotassium bisperoxo (picolinoto) oxovanadate (V)) | A bisperoxovanadium compound that acts as a potent protein phosphotyrosine phosphatase (PTP) inhibitor as well as an insulin receptor kinase (IRK) activator. Also a potent PTEN inhibitor (IC50= 31nM). Group: Biochemicals. Alternative Names: Dipotassium bisperoxo (picolinoto) oxovanadate (V). Grades: Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| bpV(pic) potassium hydrate | BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium. It is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 31 nM. It is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells and stimulating lipogenesis in adipocytes. BpV(pic) has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells and is also an inhibitor of G6Pase. Synonyms: Bisperoxovanadium(pic). Grades: ≥96%. CAS No. 148556-27-8. Molecular formula: C6H4NO7V·2K·2H2O. Mole weight: 367.3. | |
| BVT-948 | BVT 948 is a non-competitive and cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM). BVT 948 displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP, and enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Some cytochrome P450 isoforms are also suppressed by BVT 948 (IC50 <10 μM). Synonyms: BVT948; BVT-948; BVT 948; SPS8I3; SPS-8I3; SPS 8I3; 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione. Grades: ≥98% by HPLC. CAS No. 39674-97-0. Molecular formula: C14H11NO3. Mole weight: 241.24. | |
| Caffeoyltryptophan | Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC 50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase , linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes [1]. Uses: Scientific research. Group: Natural products. CAS No. 109163-69-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10002. | |
| CX08005 | CX08005 is a competitive inhibitor of PTP1B (IC50 = 0.781 μM). CX08005 binds catalytic P-loop of enzyme. It exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP. Synonyms: 2-[[[2- (Tetradecyl) phenyl]amino]carbonyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1256341-22-6. Molecular formula: C28H39N04. Mole weight: 453.61. | |
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