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| Product | Description | |
|---|---|---|
| Purmorphamine | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Purmorphamine | A 2,6,9-trisubstituted purine that promotes the differentiation of both human and murine mesenchymal progenitor cells into osteoblasts. It directly binds to and activates 7- transmembrane Smo receptor of the Hedgehog (Hh) signaling pathway. Group: Biochemicals. Alternative Names: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine. Grades: Highly Purified. CAS No. 483367-10-8. Pack Sizes: 100mg. Molecular Formula: C??H??N?O?, Molecular Weight: 520.62. US Biological Life Sciences. |  Worldwide |
| Purmorphamine | Purmorphamine Inhibitor. Uses: Scientific use. Product Category: T1810. CAS No. 483367-10-8. |  |
| Purmorphamine | Purmorphamine is a smoothened/Smo receptor agonist with an EC 50 of 1 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 483367-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-15108. |  |
| Purmorphamine | Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. Uses: Directly binds and activates smoothened (in hek293t cell:ic50= ~ 1.5 μm ); an activator of the hedgehog (hh) signaling pathway; an inducer of osteoblast differentiation (ec50= 1 μm). Synonyms: 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; purmorphamine; Purmorphamine; 483367-10-8; 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; UNII-PB12M2F8KY; Shh Signaling Antagonist VI; PB12M2F8KY; CHEMBL1221984; CHEBI:63053; C31H32N6O2; IN1132; 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine; 9-Cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenyloxy)-9H-purin-6-amine; Purmorphamine [MI]; MolMap_000073; AC1NR49A; MLS006010334; SCHEMBL1548273; CTK1D4950; AOB5391; DTXSID20415293. Grades: ≥ 98.0%. CAS No. 483367-10-8. Molecular formula: C31H32N6O2. Mole weight: 520.60. |  |
| Purmorphamine - CAS 483367-10-8 | A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC?? = 1 μM). Group: Fluorescence/luminescence spectroscopy. | |
| 2-Chloro-9-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-9H-purin-6-amine | Purmorphamine intermediate. Group: Biochemicals. Grades: Highly Purified. CAS No. 737005-53-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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