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| Product | Description | |
|---|---|---|
| PX-478 | PX-478 Inhibitor. Uses: Scientific use. Product Category: T6961. CAS No. 685898-44-6. |  |
| PX-478 | PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 685898-44-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10231. |  |
| PX-478 dihydrochloride | PX-478 is an HIF-1alpha inhibitor and an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1). PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. It is rapidly absorbed following oral and i.p. administration and gives excellent Cmax and AUC via these routes. Synonyms: PX-478 2HCl; PX-478 hydrochloride; Melphalan N-Oxide Impurity HCl; Melphalan N-Oxide Impurity hydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2). Grades: > 98%. CAS No. 685898-44-6. Molecular formula: C13H18Cl2N2O3.2HCl. Mole weight: 394.1. |  |
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