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| Product | Description | |
|---|---|---|
| Pyr10 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Pyr10 | Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-ROCE and SOCE respectively. Uses: Pyr10 is a trpc3-selective inhibitor that could be effective in the study of cellular functions. Synonyms: Pyr10; Pyr-10; Pyr 10; N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide. Grades: 98%. CAS No. 1315323-00-2. Molecular formula: C18H13F6N3O2S. Mole weight: 449.37. |  |
| TRPC3 Channel Inhibitor III, Pyr10 (N- (4- (3, 5-bis (trifluoromethyl) -1H-pyrazol-1-yl) phenyl) -4-methyl Benzene sulfonamide) | A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol-induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72uM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08uM; by Fura-2). A great complement to Pyr2, Pyr 3, and Pyr6 in Ca2+ signaling studies. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CRAC Channel Inhibitor III, Pyr6 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide) | A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46uM; by Fura-2). A great complement to Pyr2, Pyr3, and Pyr10 in Ca2+ signaling studies. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?F?N?O, Primary Target: Orai3. US Biological Life Sciences. | Worldwide |
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