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| Product | Description | |
|---|---|---|
| Pyrazine-2-carbonitrile | Pyrazine-2-carbonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 19847-12-2. Pack Sizes: 50 g. Product ID: HY-Y0131. |  |
| Pyrazine-2-carbonitrile (2-Cyanopyrazine) | 100g Pack Size. Group: Building Blocks, Organics, Pyrazines. Formula: C5H3N3. CAS No. 19847-12-2. Prepack ID 20080479-100g. Molecular Weight 105.1. See USA prepack pricing. |  |
| CCT244747 | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. Synonyms: CCT-244747; CCT 244747; 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile; 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile; (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile. Grades: ≥98%. CAS No. 1404095-34-6. Molecular formula: C20H24N8O2. Mole weight: 408.46. |  |
| CCT245737 | CCT245737 is an orally bioactive CHK1 inhibitor (IC50 of 1.4 nM), displaying >1,000-fold selectivity against CHK2 and CDK1. It potently inhibits cellular CHK1 activity (IC50 30-220nM) and enhances gemcitabine and SN38 cytotoxicity in multiple human tumor cell lines and human tumor xenograft models. It causes inhibition of tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia. Synonyms: CCT-245737; CCT 245737; CCT245737; 5-[(4-{[(2R)-morpholin-2-ylmethyl]amino}-5-(trifluoromethyl)pyridin-2-yl)amino]pyrazine-2-carbonitrile. CAS No. 1489389-18-5. Molecular formula: C16H16F3N7O. Mole weight: 379.347. | |
| CCT245737(S) | CCT245737, a nitrogen heterocycle compound, has been found to be a CHK1 inhibitor that could probable be effective in antineoplastic studies. It is still under Phase I trail for Solid tumours. IC50: 30-220 nM. Synonyms: CCT245737; CCT 245737; CCT-245737; GTPL9187; GTPL 9187; GTPL-9187; 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile. Grades: 98%. CAS No. 1489389-23-2. Molecular formula: C16H16F3N7O. Mole weight: 379.14. | |
| Pyrazinecarbonitrile,3-amino-6-(1-methylethyl)-,4-oxide(9ci) | Pyrazinecarbonitrile,3-amino-6-(1-methylethyl)-,4-oxide(9ci). Uses: Designed for use in research and industrial production. Additional or Alternative Names: CTK4J2909, AG-F-70333, 3-AMINO-6-(ISOPROPYL)PYRAZINE-2-CARBONITRILE 4-OXIDE, 50627-15-1. Product Category: Heterocyclic Organic Compound. CAS No. 50627-15-1. Molecular formula: C8H10N4O. Mole weight: 178.1912. Purity: 0.96. IUPACName: 4-hydroxy-3-imino-6-propan-2-ylpyrazine-2-carbonitrile. Product ID: ACM50627151. Alfa Chemistry ISO 9001:2015 Certified. |  |
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