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| Product | Description | |
|---|---|---|
| Quisinostat | Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation. Synonyms: JNJ-26481585; JNJ26481585; JNJ 26481585. Grades: >98%. CAS No. 875320-29-9. Molecular formula: C21H26N6O2. Mole weight: 394.479. |  |
| Quisinostat | Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan- HDAC inhibitor (HDACi), with IC 50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity [1]. Quisinostat can induce autophagy in neuroblastoma cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ-26481585. CAS No. 875320-29-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15433. |  |
| Quisinostat dihydrochloride | Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan- HDAC inhibitor with IC 50 s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ-26481585 dihydrochloride. CAS No. 875320-31-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15433A. | |
| JNJ 26481585 dihydrochloride | JNJ 26481585 dihydrochloride is a potent and second-generation pan-HDAC inhibitor (IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with antineoplastic activity. JNJ-26481585 inhibiting HDAC leads to continuous acetylation of histone H3, activation of the caspase cascade, upregulation of p21, and tumor cell apoptosis. Uses: Antitumor agent. Synonyms: JNJ 26481585 dihydrochloride; JNJ26481585 dihydrochloride; JNJ-26481585 dihydrochloride; Quisinostat HCl; N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride. Grades: 99%. CAS No. 875320-31-3. Molecular formula: C21H26N6O2.2HCl. Mole weight: 467.39. | |
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