Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Radicicol | Antibiotic. Protein tyrosine kinase inhibitor. Has antifungal, antimalarial, antiangiogenic (in vivo), anti-inflammatory and antiviral activity. Cyclooxygenase-2 (COX-2) expression inhibitor without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages. Potent HSP90 inhibitor. Anticancer compound. In vivo Rad/Raf interaction inhibitor. Inhibitor of AP-1-, NF-kappaB- and serum response factor (SRF)-mediated transcription. Suppresses expression of iNOS (NOS II). Non-competitive inhibitor of ATP citrate lyase. DNA topoisomerase VI and type II DNA topoisomerase inhibitor. Protects against LPS/IFN-gamma-induced neuronal cell death. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 12772-57-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H17ClO6. US Biological Life Sciences. |  Worldwide |
| Radicicol | Radicicol is an inhibitor of Hsp90 with an IC 50 value < 1 μM, and leads to proteasomal degradation [1]. Radicicol exhibits inhibition on PDK with IC 50 s of 230 μM ( PDK1 ) and 400 μM ( PDK3 ). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB [2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein ( FTO ), with an IC 50 value of 16.04 μM [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Monorden. CAS No. 12772-57-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6769. |  |
| Radicicol | Radicicol is an inhibitor of Hsp90 with an IC50 value < 1 μM, and leads to proteasomal degradation. Group: Inhibitors. Alternative Names: Monorden. CAS No. 12772-57-5. Molecular formula: C18H17ClO6. Mole weight: 364.8. Purity: 95%+. IUPACName: (4R,6R,8R,9Z,11E)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione. Canonical SMILES: CC1CC2C (O2)C=CC=CC (=O)CC3=C (C (=CC (=C3Cl)O)O)C (=O)O1. Density: 1.364±0.06 g/cm³. Catalog: ACM12772575. |  |
| Radicicol (Monorden) | Radicicol is a resorcylic acid lactone produced by several fungal species that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and been shown to inhibit protein tyrosine kinase, induce the differentiation of HL-60 cells into macrophages, block cell cycle at G1 and G2, suppress NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppress the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells. Group: Biochemicals. Alternative Names: Monorden. Grades: Highly Purified. CAS No. 12772-57-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (3-Benzyloxypropyl) triphenylphosphonium Bromide | (3-Benzyloxypropyl) triphenylphosphonium Bromide is a reagent used in the preparation of antitumor and Her2 degradation activity of geldanamycin and radicicol macrocyclic chimeras. Group: Biochemicals. Grades: Highly Purified. CAS No. 54314-85-1. Pack Sizes: 1g, 10g. Molecular Formula: C28H28BrOP, Molecular Weight: 491.4. US Biological Life Sciences. | Worldwide |
| androst-4-ene-3,17-dione monooxygenase | Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC 1.14.13.54, ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.4, progesterone monooxygenase. Group: Enzymes. Synonyms: androstene-3,17-dione hydroxylase; androst-4-ene-3,17-dione 17-oxidoreductase; androst-4-ene-3,17-dione hydroxylase; androstenedione monooxygenase; 4-androstene-3,17-dione monooxygenase. Enzyme Commission Number: EC 1.14.99.12. CAS No. 37256-74-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1033; androst-4-ene-3,17-dione monooxygenase; EC 1.14.99.12; 37256-74-9; androstene-3,17-dione hydroxylase; androst-4-ene-3,17-dione 17-oxidoreductase; androst-4-ene-3,17-dione hydroxylase; androstenedione monooxygenase; 4-androstene-3,17-dione monooxygenase. Cat No: EXWM-1033. |  |
| KF-25706 | KF25706 is derivative of radicicol that binds to the Hsp90 chaperone machinery with IC50 of 39 nM. Synonyms: KF-25706; KF 25706; KF25706; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-oxime, (1aS,?2Z,?4E,?14R,?15aS)?-,UCS1006-S15. Grades: >98%. CAS No. 184537-25-5. Molecular formula: C18H18ClNO6. Mole weight: 379.79. |  |
| KF-55823 | KF55823 is a derivative of radicicol that binds to the Hsp90 chaperone machinery. Synonyms: KF-55823; KF 55823; KF55823. Grades: >98%. CAS No. 452083-20-4. Molecular formula: C24H27ClN2O7. Mole weight: 490.94. | |
| KF-58333 | KF58333 is a novel derivative of radicicol that binds to the Hsp90 chaperone machinery, depletes p210Bcr-Abl and Raf-1 proteins followed by induction of erythroid differentiation and G1 phase accumulation, and induces apoptosis in human CML cells. Synonyms: KF-58333; KF 58333; KF58333; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-[O-[2-(2-oxo-1-pyrrolidinyl)?ethyl]?oxime]?, (1aR,?2Z,?4E,?6E,?14R,?15aR)?- (9CI). Grades: >98%. CAS No. 308244-21-5. Molecular formula: C24H27ClN2O7. Mole weight: 490.93. | |
| Monorden A | Monorden A is a metabolite of Humicola sp. FO-2942. It has the effect of arresting the cell cycle of Jurket cells in G1 and G2/M phases. It has anti-Aspergillus niger activity. It inhibits Hsp90 activity by binding to the ATP-binding pocket, thus suppressing cell transformation induced by src, ras and mos. Synonyms: radicicol. Grades: >98%. CAS No. 12772-57-5. Molecular formula: C18H17ClO6. Mole weight: 364.78. | |
| progesterone monooxygenase | Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase. Group: Enzymes. Synonyms: progesterone hydroxylase. Enzyme Commission Number: EC 1.14.99.4. CAS No. 37256-85-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1051; progesterone monooxygenase; EC 1.14.99.4; 37256-85-2; progesterone hydroxylase. Cat No: EXWM-1051. | |
| Ratester | Radester is a hybrid composed of radicicol's resorcinol and geldanamycin's benzoquinone part structures and exhibits good cellular activity against MCF7 breast cancer cells, accompanied by degradation of the Hsp90 clients HER-2 and c-Raf. Synonyms: CHEMBL578372; CHEMBL 578372; CHEMBL-578372; SCHEMBL10186763; SCHEMBL 10186763; SCHEMBL-10186763. Grades: >98%. CAS No. 854485-83-9. Molecular formula: C18H16ClNO8. Mole weight: 409.77. | |
Our database is helping our users find suppliers everyday.
