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| Product | Description | |
|---|---|---|
| Rebeccamycin | Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II. Synonyms: 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-; 1,11-dichloro-12-(4-O-methyl-beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; (Rebeccamycin)1,11-dichloro-12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2H-2-pyranyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; 1,11-dichloro-12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2H-2-pyranyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; 1,11-dichloro-12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2H-2-pyranyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione(rebeccamycin); 1,11-dichloro-12-[3,4-dihydroxy-6-hydroxymethyl-5-methoxy-(2R,3R,4S,5R,6R)-tetrahydro-2H-2-pyranyl]-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; dichloro-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl][?]dione. Grades: >98.0%. CAS No. 93908-02-2. Molecular formula: C27H21Cl2N3O7. Mole weight: 570.38. |  |
| Rebeccamycin | Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. It displays a selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin are currently in several clinical trials for cancer therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 93908-02-2. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Rebeccamycin (NSC 359079, BRN 4732638) | Antibiotic. Weak topoisomerase I (Topo I) inhibitor. Structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 93908-02-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| 4'-demethylrebeccamycin synthase | This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole. Group: Enzymes. Synonyms: arcyriaflavin A N-glycosyltransferase; RebG. Enzyme Commission Number: EC 4.3.3.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5306; 4'-demethylrebeccamycin synthase; EC 4.3.3.5; arcyriaflavin A N-glycosyltransferase; RebG. Cat No: EXWM-5306. |  |
| Becatecarin (6-N-[2- (Diethylamino) ethyl]rebeccamycin, NSC 655649, BMY-27557-14, BMS-181176, XL119) | Antibiotic. Semisynthetic H2O-soluble derivative of rebeccamycin. Antitumor compound. Topoisomerase II (Topo II) inhibitor. DNA intercalating agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 119673-08-4. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| demethylrebeccamycin-D-glucose O-methyltransferase | Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers. The enzyme is a member of the general acid/base-dependent O-methyltransferase family. Group: Enzymes. Synonyms: RebM. Enzyme Commission Number: EC 2.1.1.164. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1761; demethylrebeccamycin-D-glucose O-methyltransferase; EC 2.1.1.164; RebM. Cat No: EXWM-1761. | |
| 7-chloro-L-tryptophan oxidase | Contains a noncovalently bound FAD. This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide. The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan. Group: Enzymes. Synonyms: RebO. Enzyme Commission Number: EC 1.4.3.23. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1478; 7-chloro-L-tryptophan oxidase; EC 1.4.3.23; RebO. Cat No: EXWM-1478. | |
| Becatecarin | Becatecarin is a synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. Synonyms: NSC 655649; BMS 181176; BMY 27557; 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-. Grades: ≥95%. CAS No. 119673-08-4. Molecular formula: C33H34Cl2N4O7. Mole weight: 669.55. | |
| dichloroarcyriaflavin A synthase | The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine. Group: Enzymes. Enzyme Commission Number: EC 1.13.12.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0609; dichloroarcyriaflavin A synthase; EC 1.13.12.17. Cat No: EXWM-0609. | |
| dichlorochromopyrrolate synthase | This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center. In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC 1.4.3.23, 7-chloro-L-tryptophan oxidase) as the electron acceptor. However, the enzyme is also able to catalyse the reaction using molecular oxygen. Group: Enzymes. Synonyms: RebD; chromopyrrolic acid synthase; chromopyrrolate synthase. Enzyme Commission Number: EC 1.21.98.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1261; dichlorochromopyrrolate synthase; EC 1.21.98.2; RebD; chromopyrrolic acid synthase; chromopyrrolate synthase. Cat No: EXWM-1261. | |
| tryptophan 7-halogenase | In the bacterium Lechevalieria aerocolonigenes the enzyme catalyses the initial step in the biosynthesis of rebeccamycin. Also acts on bromide ion. Group: Enzymes. Synonyms: PrnA; RebH. Enzyme Commission Number: EC 1.14.19.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1016; tryptophan 7-halogenase; EC 1.14.19.9; PrnA; RebH. Cat No: EXWM-1016. | |
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