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| Product | Description | |
|---|---|---|
| Regorafenib monohydrate | Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC 50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 , respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506 monohydrate. CAS No. 1019206-88-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10331A. |  |
| Regorafenib monohydrate | Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2. Synonyms: BAY 73-4506. Grades: >98%. CAS No. 1019206-88-2. Molecular formula: C21H17ClF4N4O4. Mole weight: 500.83. |  |
| Regorafenib monohydrate impurity B [EP] | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 02; 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide. CAS No. 2141961-84-2. Molecular formula: C15H14FN3O3. Mole weight: 303.29. | |
| Regorafenib monohydrate impurity C [EP] | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpyridine-2-carboxamide; 4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide. CAS No. 1855006-12-0. Molecular formula: C20H18FN5O3. Mole weight: 395.39. | |
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