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| Product | Description | |
|---|---|---|
| Resiniferatoxin | Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Resiniferatoxin. CAS No. 57444-62-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2333. |  |
| 5'-Iodoresiniferatoxin | 5'-Iodoresiniferatoxin is a very potent and strong competitive antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It is derived from resiniferatoxin (RTX), which is produced by the Moroccan succulent Euphorbia resinifera. It is iodinated at the 5-position and can be prepared from RTX by electrophilic aromatic substitution. It binds to TRPV1 (VR1) receptors expressed in HEK293 cells with Kd value of 4.3 nM and Ki value of 5.8 nM. It binds to the VR1 receptor with high affinity but does not induce RTX- or capsaicin-like effects in Xenopus laevis oocytes expressing VR1. It is 40-fold more potent than capsazepine. Synonyms: 5-I-RTX; 5'-IRTX; 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzeneacetate). Grades: ≥98% by HPLC. CAS No. 535974-91-5. Molecular formula: C37H39IO9. Mole weight: 754.60. |  |
| 2- (4- (Methylsulfonamido) phenyl) acetic Acid | 2- (4- (Methylsulfonamido) phenyl) acetic Acid acts as a reagent for resiniferatoxin analogs preparation as metabolically stable TRPV1 agonists and potential analgesics. Preparation and structure-activity relationships of 2, 6-diaryl-4- (phenacylamino) pyrimidines as selective adenosine A2A antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 56205-88-0. Pack Sizes: 250mg, 1g. Molecular Formula: C9H11NO4S. US Biological Life Sciences. |  Worldwide |
| PDDHV | PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat vanilloid receptor VR1 (TRPV1). It evoked 45Ca2+-uptake by rat dorsal root ganglion neurons in culture. Synonyms: Phorbol 12,13-didecanoate 20-homovanillate. Grades: ≥99%. CAS No. 179469-40-0. Molecular formula: C49H72O11. Mole weight: 837.1. | |
| Resiniferonol 9,13,14-Orthophenylacetate | Resiniferonol 9,13,14-Orthophenylacetate, a 20-Deacylated derivative of resiniferatoxin and tinyatoxin, is a transient receptor potential vanilloid-1 (TRPV1) agonist. Synonyms: 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)daphnetoxin; [2S-(2α, 3aβ, 3bβ, 6aβ, 9aα, 9bα, 10α, 11aβ)]-3a, 3b, 6, 6a, 9a, 10, 11, 11a-Octahydro-6a-hydroxy-5-(hydroxymethyl)-8, 10-dimethyl-11a-(1-methylethenyl)-2-(phenylmethyl)-7H-2, 9b-Epoxyazuleno[5, 4-e]-1, 3-benzodioxol-7-one; Resiniferonol 9,13,14-ortho-phenylacetate; 57852-42-3; CTK8G2927. CAS No. 57852-42-3. Molecular formula: C28H32O6. Mole weight: 464.55. | |
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