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| Product | Description | |
|---|---|---|
| Resminostat hydrochloride | Resminostat hydrochloride is a potent inhibitor of HDAC1 , HDAC3 and HDAC6 , with mean IC 50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC 50 of 877 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RAS2410 hydrochloride; 4SC-201 hydrochloride. CAS No. 1187075-34-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14718A. |  |
| Resminostat hydrochloride | Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6. As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266. This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53. In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study. Synonyms: RAS2410 hydrochloride; 4SC-201 hydrochloride; 4SC 201 hydrochloride; 4SC201 hydrochloride; RAS 2410 hydrochloride; RAS-2410 hydrochloride. Grades: >98%. CAS No. 1187075-34-8. Molecular formula: C16H20ClN3O4S. Mole weight: 385.87. |  |
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