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| Product | Description | |
|---|---|---|
| Rhosin | Rhosin is a specific Rho inhibitor, which binds to WT RhoA with an affinity ~0.4 μM Kd and does not interfere with the binding of Cdc42 or Rac1. Synonyms: Rhosin; G04; G-04; G 04. Grades: >98%. CAS No. 1173671-63-0. Molecular formula: C20H18N6O. Mole weight: 358.4. |  |
| Rhosin hydrochloride | Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF. Synonyms: Rhosin hydrochloride. Grades: >98%. CAS No. 1281870-42-5. Molecular formula: C20H19ClN6O. Mole weight: 394.86. | |
| Rhosin hydrochloride | Rhosin hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 1281870-42-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H18N6O HCl 1.25 H2O, Molecular Weight: 417.38. US Biological Life Sciences. |  Worldwide |
| Rho Inhibitor, Rhosin ( (2R) -2-Amino-3- (1H-indol-3-yl) -N'- ( (1E) -quinoxalin-6-ylmethylidene) propanehydrazide, G04) | A cell-permeable (quinoxalinyl methyl idene-D-Tryptophanyl) hydrazide that directly targets Rho GEF binding domain (Kd = 354nM for RhoA), thereby prevents Rho from interacting with its GEFs (including LARG, DBL, LBC, p115 RhoGEF, and PDZ RhoGEF), but not p190RhoGAP, RhoGDI, or its effectors (ROCK, mDia, PKN, Rhoteckin). Shown to inhibit serum-induced RhoA, RhoB, and RhoC, but not Cdc42 or Rac1, activation, MLC & PAK phosphorylation, as well as stress fiber & focal complex formation in serum-starved NIH3T3 cultures (Effective conc. 30uM) in a reversible manner. Group: Biochemicals. Grades: Highly Purified. CAS No. 1173671-63-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Primary Target: Rho GTPase. US Biological Life Sciences. | Worldwide |
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