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| Product | Description | |
|---|---|---|
| Rhosin hydrochloride | Rhosin hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 1281870-42-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H18N6O HCl 1.25 H2O, Molecular Weight: 417.38. US Biological Life Sciences. |  Worldwide |
| Rhosin hydrochloride | Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1281870-42-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12646. |  |
| Rho Inhibitor, Rhosin ( (2R) -2-Amino-3- (1H-indol-3-yl) -N'- ( (1E) -quinoxalin-6-ylmethylidene) propanehydrazide, G04) | A cell-permeable (quinoxalinyl methyl idene-D-Tryptophanyl) hydrazide that directly targets Rho GEF binding domain (Kd = 354nM for RhoA), thereby prevents Rho from interacting with its GEFs (including LARG, DBL, LBC, p115 RhoGEF, and PDZ RhoGEF), but not p190RhoGAP, RhoGDI, or its effectors (ROCK, mDia, PKN, Rhoteckin). Shown to inhibit serum-induced RhoA, RhoB, and RhoC, but not Cdc42 or Rac1, activation, MLC & PAK phosphorylation, as well as stress fiber & focal complex formation in serum-starved NIH3T3 cultures (Effective conc. 30uM) in a reversible manner. Group: Biochemicals. Grades: Highly Purified. CAS No. 1173671-63-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Primary Target: Rho GTPase. US Biological Life Sciences. | Worldwide |
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