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| Product | Description | |
|---|---|---|
| Rhosin hydrochloride | Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF. Synonyms: Rhosin hydrochloride. Grades: >98%. CAS No. 1281870-42-5. Molecular formula: C20H19ClN6O. Mole weight: 394.86. |  |
| Rhosin hydrochloride | Rhosin hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 1281870-42-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H18N6O HCl 1.25 H2O, Molecular Weight: 417.38. US Biological Life Sciences. |  Worldwide |
| Rhosin hydrochloride | Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1281870-42-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12646. |  |
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