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| Product | Description | |
|---|---|---|
| Ribociclib | Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. Synonyms: LEE011; LEE 011; LEE-011; Kisqali. CAS No. 1211441-98-3. Molecular formula: C23H30N8O. Mole weight: 434.55. |  |
| Ribociclib | RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor with IC 50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex [1] [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LEE011. CAS No. 1211441-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15777. |  |
| Ribociclib hydrochloride | Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC 50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LEE011 hydrochloride. CAS No. 1211443-80-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15777A. | |
| Ribociclib succinate | Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC 50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LEE011 succinate. CAS No. 1374639-75-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15777B. | |
| Ribociclib succinate hydrate | Ribociclib succinate hydrate (LEE011 succinate hydrate) is a highly specific CDK4/6 inhibitor with IC 50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LEE011 succinate hydrate. CAS No. 1374639-79-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15777C. | |
| LEE011 hydrochloride | CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.Treatment with LEE011 significantly reduced proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis at nanomolar concentrations (mean IC50=307 ± 68 nmol/L in sensitive lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. Responsiveness of neuroblastoma xenografts to LEE011 translated to the in vivo setting in that there was a direct correlation of in vitro IC50 values with degree of subcutaneous xenograft growth delay. Synonyms: 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride; Ribociclib hydrochloride; LEE011; LEE-011 LEE 011. Grades: >98%. CAS No. 1211443-80-9. Molecular formula: C23H31ClN8O. Mole weight: 471.0. | |
| LEE011 succinate | LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models. Synonyms: Ribociclib succinate; LEE 011 succinate; LEE-011 succinate. Grades: >98%. CAS No. 1374639-75-4. Molecular formula: C27H36N8O5. Mole weight: 552.63. | |
| LEE011 succinate hydrate | LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Synonyms: Ribociclib succinate hydrate; LEE 011 succinate hydrate; LEE-011 succinate hydrate. Grades: >98%. CAS No. 1374639-79-8. Molecular formula: C27H38N8O6X. Mole weight: 570.64. | |
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